SourceOne Announces Human Study Results

SourceOne Global Partners has announced the results of a study comparing the absorption and bioavailability of the key ingredient in Cholesstrinol™ HP, PMF-Source™ Citrus Polymethoxylated Flavones (PMF) with the patented VESIsorb® Delivery System, to standard PMF powder. The bioavailability pilot study (single oral dose, double-blind, crossover design) showed that both Nobiletin and Tangeretin in the standard PMF powder and VESIsorb® formulation were absorbed and extensively metabolized. The PMF absorption of the VESIsorb® formulation was significantly improved and faster (Tmax) compared to the standard PMF powder. Peak plasma levels (Cmax) of Nobiletin, Tangeretin and their metabolites were increased up to 800%.

“It is widely accepted in the scientific and medical community that Citrus PMFs are notoriously poorly absorbed in the body,” stated Dr. Andreas Supersaxo, Director of Research and Development, Vesifact, the Baar, Switzerland-based innovator and patent holder of VESIsorb®. “Our team of scientists who collaborated on this research finds these breakthrough results extremely compelling. They represent clear potential for greater efficacy and improved health and wellness for formulations containing Citrus PMF, HO-PMFs, Citrus Limonoids, and Eriocitrin/Eriodictyol.”

Rob Brewster, President of Ingredients By Nature, commented, “SourceOne has pioneered the commercial development globally of PMFs, and continues to lead in further enhancing the value of PMFs in multiple formulations, broader applications and health conditions.”
Recent research has focused on the anti-inflammatory role of Citrus PMFs, Limonoids and Eriocitrin / Eriodictyol. “Many leaders in the medical community view chronic inflammation as an equally or even more important marker for cardiovascular health than cholesterol or triglyceride levels, and they continue to focus on supplementing with citrus extracts, like PMFs, for their extensive benefits for reducing incidence against chronic inflammation.” noted Dr. Supersaxo. “Chronic inflammation has become a significant factor, not only for cardiovascular health, but overall health and wellness.”

SourceOne has formed exclusive partnerships with Ingredients by Nature (Montclair, CA), the world leader in production and supply of Citrus
Bioflavonoids, PMF and Limonoids, and Vesifact AG.

“Our leadership team’s ongoing success in forging numerous global natural ingredient supply partnerships and research and development alliances results in competitive advantages and added value to the natural product portfolio we bring to the global marketplace,” said Jesse Lopez, founder and CEO of SourceOne Global Partners. “The synergies created by these partnerships are directly and immediately applicable to the new products we are introducing and those we are developing. The many benefits derived from these innovations and the technology exchange will resonate with our client partners and ultimately the consumer focused on health and wellness.”

PMF-source™ is the latest of many SourceOne bioactives that have achieved dramatic results in bioavailability and absorption when utilizing the VESIsorb® technology:

CoQsource® Q10 Ubiquinone
The peer-reviewed journal, Alternative Therapies in Health and Medicine, recently published the results of a double-blind study comparing the bioavailability of patented CoQsource® Bio-Enhanced CoQ10 (exclusive brand of SourceOne) to that of other “bio-enhanced” CoQ10 formulations. The study, entitled, “Relative Bioavailability Comparison of Different Coenzyme Q10 Formulations with a Novel Delivery System,” appears in the March/April, 2009 issue, Vol. 15, No. 2.

In this study, the relative bioavailability of a single oral dose of 120mg of CoQ10 was assessed using the area under curve [AUC (0-10h)] where the value for CoQsource® reached 30.62 µg/ml/10h; a far superior 622% higher bioavailability than the oil-based formula.

CoQsource® QH-Ubiquinol
A pharmacokinetic pilot study (single oral dose, crossover) in humans comparing Ubiquinol-QH to the same Ubiquinol-QH in the VESIsorb® delivery system (CoQsource® QH exclusively from SourceOne) demonstrated an increase of 696% in peak blood levels (cmax) of Ubiquinol. The relative bioavailability calculated using the area under the curve (AUC0-24h) was also increased by 485%.

OmegaChoice™ Concentrated Omega-3 EPA/DHA
A pharmacokinetic study (single oral dose, crossover) in humans comparing OmegaChoice™ 90 Concentrated Omega-3 EPA to the same OmegaChoice™ 90 in the VESIsorb® delivery system demonstrated an increase of 567% in peak blood levels (cmax) of EPA. The relative bioavailability calculated using the area under the curve (AUC0-12h) was also increased by 487%.

Marc Weder, co-founder and CEO of Vesifact, commented, “These results, including the newest study, highlight the many advantages that this delivery system represents. We have been able to broaden the applications for certain bioactive ingredients like PMFs, CoQ10, and Omega-3 into functional foods, drink mixes, beverages, and cosmetic products. We have succeeded in this area by addressing issues such as water solubility, oxidative stability, shelf life and uniformity of dispersion in the delivery medium.”

Lopez added, “VESIsorb® enables us to meet the growing demand for enhanced bioavailability of unique science-based ingredients and proprietary formulas taking their absorption and efficacy to the next level, truly making SourceOne the industry’s first choice for heart-healthy ingredient solutions.”

About SourceOne Global Partners
SourceOne Global Partners, headquartered in Chicago, IL, is a leading supplier of innovative, science-based, branded ingredients and proprietary formulas to the nutritional supplement, functional food & beverage, cosmetic, and animal nutrition markets. SourceOne has assembled an impressive and enviable portfolio of complementary condition-specific ingredients that address the most pressing health concerns, including heart health, Type II diabetes, cognitive function, diet and energy, and general wellness.

SourceOne is recognized as a leader in delivering the best science nature has to offer through health solutions such as the award-winning Cholesstrinol™ Family of Heart Healthy Formulas, OmegaChoice™ Marine Concentrated Omega-3 EPA/DHA (EFAs), CoQsource® Bio-Enhanced Coenzyme Q10, and SterolSource® Phytosterols. The SourceOne product line continues to expand and also includes TocoSource® Palm Tocotrienols, GammaSource® Mixed Tocopherols, PMF-source™ Citrus Flavonoids (PMF), Tongkat Ali-Source™ as well as Green Tea, Resveratrol, Chondroitin, Natural Carotenoids, and more.

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