Study claim: Sterols and fibre, when delivered in a cookie format, lower cholesterol levels.
Published: Shrestha S, et al. A combination therapy including psyllium and plant sterols lowers LDL cholesterol by modifying lipoprotein metabolism in hypercholesterolemic individuals. J Nutr 2006;136:2492—7.
Abstract: In a randomised, double-blind, crossover, placebo-controlled study, researchers determined the effects of a combination therapy including plant sterols (PS) and psyllium (PSY), provided via cookies, on plasma lipids and on the size and subfraction distribution of VLDL, LDL and HDL. A total of 33 healthy free-living individuals (11 males and 22 females), aged 35-65 years, with a body mass index (BMI) between 25 and 35kg/m2 and initial plasma LDL cholesterol (LDL-C) concentrations between 2.6 and 4.1mmol/L (100 and 160mg/dL), were randomly assigned to receive treatment cookies (7.68g/d PSY and 2.6g/d PS) or placebo cookies (0g PSY1PS) for four weeks.
After a three-week washout period, subjects received the other cookies for an additional four weeks. Plasma total cholesterol concentrations were significantly reduced for all subjects, from 5.65 +/- 0.72 mmol/L after the placebo period to 5.28 +/-0.76mmol/L after the PSY1PS cookie period. These reductions were primarily in LDL-C, which decreased from 3.48 to 3.14mmol/L after PSY1PS cookie consumption. Intake of the PSY1PS cookies decreased the number of intermediate density lipoprotein (IDL), LDL, and HDL particles and plasma apo B concentrations. The decreases in LDL and HDL particles were in the small sub-fractions.
Because smaller LDL particles are associated with an increased risk of heart disease and because smaller HDL particles are indicative of diminished reverse cholesterol transport, the researchers concluded that the combination therapy resulted in a less atherogenic lipoprotein profile. In addition, the evaluation of lipoprotein sub-fractions resulting from the action of the fibre and plant sterols in the intestinal lumen provides an insight on the secondary mechanisms of plasma LDL-C lowering.
Potential applications: The company's debut product, Right Direction Cookies, is a chocolate chip cookie that helps consumers manage cholesterol and add quality fibre to their diets.
+1 866 535 3696
Study claim: DSM's combination ingredient of lutein and OPTISHARP zeaxanthin can improve vision.
Published: Kvansakul J, et al. Supplementation with the carotenoids lutein and zeaxanthin improves human visual performance. Ophthal Physiol Opt 2006;26;362-71. Rodriguez-Carmona M, et al. The effects of supplementation with lutein and/or zeaxanthin on human macular pigment density and colour vision. Ophthal Physiol Opt 2006;26;137-47.
The second study, carried out by the same research group, investigated the effect of lutein and OPTISHARP on colour vision. This was carried out by measuring 'human chromatic discrimination sensitivity,' the ability of the human eye to differentiate between colours. The results demonstrate that lutein and OPTISHARP can improve colour vision.
Potential applications: OPTISHARP is available for supplemental formulas.