Study claim: Daily dose of a tomato extract, Lyc-O-Mato, helped lower moderately elevated blood pressure.
Published: Engelhard YN, et al. Natural antioxidants from tomato extract reduce blood pressure in patients with grade-1 hypertension: a double-blind, placebo-controlled pilot study. Am Heart J 2006 Jan; 151(1):100.
Abstract: Treating hypertension (HT) can reduce the risk for cardiovascular diseases. Tomato extract contains carotenoid antioxidants such as lycopene, beta-carotene and vitamin E, which slow the progression of atherosclerosis. The purpose of this single-blind, placebo-controlled study was to evaluate the effect of tomato extract on systolic and diastolic blood pressure in grade-1 HT, on serum lipoproteins, plasma homocysteine, and oxidative stress markers.
Thirty one subjects with grade-1 HT, without concomitant diseases, who required no antihypertensive or lipid-lowering drug therapy, completed the trial. Subjects entered a four-week placebo period, then an eight-week treatment period with tomato extract, 250mg Lyc-O-Mato, and a four-week control period with placebo.
Systolic blood pressure decreased from 144 (SE +/- 1.1) to 134mm Hg (SE +/- 2), and diastolic blood pressure decreased from 87.4 (SE +/- 1.2) to 83.4mm Hg (SE +/- 1.2). Both changes are significant. No changes in blood pressure were demonstrated during placebo periods. Thiobarbituric acid-reactive substances, a lipid peroxidation products marker, decreased from 4.58 (SE +/- 0.27) to 3.81nmol/mg (SE +/- 0.32). No significant changes were found in lipid parameters.
A short-term treatment with antioxidant-rich tomato extract can reduce blood pressure in patients with grade-1 HT, naive to drug therapy. The continuous effect of this treatment and the long-term beneficial effect on cardiovascular risk factors still need to be demonstrated.
Potential applications: Lyc-O-Mato tomato extract provides a full complement of carotenoids and other naturally occurring tomato antioxidants. It promotes cardiovascular health and also supports prostate health. It is ideal for soft-gel encapsulation and also as a powder for food and beverage integration.
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Study claim: Tocomin natural full-spectrum palm tocotrienol complex acts on key molecular checkpoints to protect against glutamate- and stroke-induced neurodegeneration.
Published: Khanna S, et al. Neuroprotec-tive properties of the natural vitamin E alpha-tocotrienol. Stroke 2005 Oct; 36(10):2258-64.
Abstract: The current work, funded by the National Institutes of Health, is based on our previous finding that in neuronal cells, nmol/L concentrations of alpha-tocotrienol (TCT), but not alpha-tocopherol (TCP), blocked glutamate-induced death by suppressing early activation of c-Src kinase and 12-lipoxygenase.
The single neuron microinjection technique was used to compare the neuroprotective effects of TCT with that of the more widely known TCP. Stroke-dependent brain tissue damage was studied in 12-Lox-deficient mice and spontaneously hypertensive rats orally supplemented with TCT.
Subattomole quantity of TCT, but not TCP, protected neurons from glutamate challenge. Pharmacological as well as genetic approaches revealed that 12-Lox is rapidly tyrosine phosphorylated in the glutamate-challenged neuron and that this phosphorylation is catalysed by c-Src. 12-Lox-deficient mice were more resistant to stroke-induced brain injury than their wild-type controls.
Oral supplementation of TCT to spontaneously hypertensive rats led to increased TCT levels in the brain. TCT-supplemented rats showed more protection against stroke-induced injury compared with matched controls. Such protection was associated with lower c-Src activation and 12-Lox phosphorylation at the stroke site.
Potential applications: Tocomin is available as a supplement, functional ingredient in oil and fats systems, a water-dispersible emulsion or powder, and cosmetics and personal care products.
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