SelenoExcell Receives Independent GRAS Evaluation

Cypress Systems branded ingredient in selected food categories at a combined level to yield up to 150 microgram per day as selenium is GRAS.

(Fresno, CA) November 13, 2006 – Cypress Systems, a leading biotechnology company based in Fresno, CA, has received independent GRAS (Generally Recognized As Safe) designation for its flagship product SelenoExcell® High Selenium Yeast use in several food categories. According to Paul A. Willis, Cypress Systems president, the evaluation was based on scientific procedures and the safety assessment criteria established by the U.S. Food and Drug Administration.

The assessment included consideration of the manufacturing process and quality assurance procedure used to produce the subject material with its associated specifications. Results from animal testing that address the safety and/or toxicity of SelenoExcell® and other chemical forms of selenium were considered, as were the various clinical testing results and documented human experience investigations that have been published over the past four

decades. Up to 150 micrograms per day of the selenium content can be safely added to various food categories including baked goods, non-alcoholic beverages, grains, pastas and soups.

SelenoExcell® is supported by a Clinical Trial Agreement with the Cancer Prevention Division of the National Cancer Institute and is used as the sole intervention agent in a series of "Gold Standard" cancer prevention and health-related trials.

Interest in high selenium yeast heightened in 1996 when the Journal of the American Medical Association (JAMA), published results from

Dr. Larry C. Clark’s Nutritional Prevention of Cancer (NPC) trial. The trial showed that high selenium yeast cut overall cancer death rates by 50%, prostate cancer incidence by 63%, lung cancer 46% and colon cancer by 58%. Following the study’s publication, the NPC study was unblinded and extended with funding from NCI utilizing SelenoExcell®.
For more information about SelenoExcell® contact Paul A. Willis at 559.229.7850 or visit

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