In Vitro Study Reveals Potential Weight Loss Effects of Mangosteen Juice Supplement Mango-xan

Results to be Presented at the American Chemical Society's Northwest Regional Meeting

AMERICAN FORK, Utah, June 11, 2007 - The results of a recent in-vitro study show that compounds in Mango-xan, a mangosteen juice supplement from Pure Fruit Technologies, bound with B-1 and B-3 adrenergic receptor cells. This binding significantly stimulated the production of enzymes linked to increasing energy and fat metabolism. The study results will be presented at the American Chemical Society's 62nd Annual Northwest Regional Meeting being held June 17 - 20, 2007 in Boise, Idaho.

Using established protocols, human B-1 and B-3 adrenergic receptors cells were isolated. The cells were then exposed to Mango-xan in different concentrations: 1 percent (1 mg per mL of water) and 2.5 percent (2.5 mg per mL of water). At concentrations of 1 and 2.5 percent Mango-xan stimulated B-1 adrenergic receptors by 38 percent and 58 percent respectively. At the same concentrations, Mango-xan stimulated B-3 adrenergic receptors by 453 percent and 463 percent respectively.

B?adrenergic receptors are linked to G proteins, which are involved in secondary messenger cascades that transduce signals into a cellular change.? G proteins are linked to adenylyl cyclase, the main enzyme involved in the production of cyclic adenosine monophosphate (cAMP). cAMP contributes to the activation of protein kinase A (PKA), which increases metabolism and promotes lipid breakdown.

"The results show that Mango-xan has the potential to be used as a weight management tool in conjunction with a proper diet and exercise," stated Wayne Geilman, Ph.D., senior research scientist.? "Future research is needed to determine dosage and efficacy of Mango-xan using human clinical trials."

For more information on this study visit and scroll down to page 98.

Pure Fruit Technologies is a Utah-based manufacturer of healthy, exotic, whole-fruit juice supplements. The company has searched the globe for exotic fruits that deliver an array of health benefits, including mangosteen, seabuckthorn, goji and gac, and brought them to consumers in the form of potent, high quality and delicious juice supplements. Founded in 2002, Pure Fruit Technologies' first product was Mango-xan(R) Antioxidant Recovery Formula. The company has expanded its offerings to include Seabuck-7(TM) Rejuvenation Formula, Goji-Zen(TM) Longevity Formula and Gac-Chi(TM) Heart & Vision Formula. Pure Fruit Technologies' products are made from the whole fruit and are sold wholesale to health food retailers and distributors worldwide, as well as direct-to-consumers online. To learn more about Pure Fruit Technologies visit

The American Chemical Society is a self-governed individual membership organization that consists of more than 158,000 members at all degree levels and in all fields of chemistry. The organization provides a broad range of opportunities for peer interaction and career development, regardless of professional or scientific interests. The programs and activities conducted by ACS today are the products of a tradition of excellence in meeting member needs that dates from the Society's founding in 1876.? For more information visit

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