Pregnancy & Supplement Safety
By Jeremy Appleton, ND, CNS
Healthnotes Newswire (May 13, 2010)—During pregnancy and while breast-feeding, women’s nutritional needs change. Some vitamins, minerals, and herbs are unsafe to take during pregnancy, even if they are safe or necessary at other times. Always consult with your doctor if you are pregnant and you want to take a nutritional or herbal supplements of any kind. A good rule of thumb is to avoid any supplements unless they are necessary.
Which vitamins and minerals are needed during pregnancy?
The Recommended Dietary Allowance (RDA) for many vitamins and minerals increases during pregnancy. The vitamins and minerals listed below are only selected examples of the many required by pregnant women. A high-quality prenatal multivitamin is a good way for many women to meet additional needs for vitamins and minerals. Pregnant women should consult with their doctor at the beginning of prenatal care to determine how best to meet their specific nutritional needs.
• Folic acid :The body’s folic acid need more than doubles during pregnancy. Folic acid deficiencies during pregnancy have been linked to low birth weight and to an increased incidence of neural tube defects (such as spina bifida) in infants. Most healthcare professionals recommend that women of childbearing age supplement with 400 to 800 mcg per day. Folic acid should be taken even before a woman knows she is pregnant and throughout the entire pregnancy. Folic acid supplementation is important prior to conception because it provides its protection in the first weeks of pregnancy before a woman knows she has conceived. Waiting to begin supplementation until after you know you are pregnant may increase the risk of birth defects. Most prenatal multivitamins contain sufficient folic acid.
• Iron: The need for iron increases during pregnancy. The highest risk for iron deficiency occurs in the last weeks of pregnancy. Healthy nonpregnant women should not supplement with iron unless they have an iron deficiency proven by a blood test. Many, but not all, pregnant women eventually require iron supplementation during pregnancy, usually around 45 mg per day. Pregnant women may help increase the birth weight of their babies by taking iron supplements before 20 weeks’ gestation. Women should consult with their doctor to find out if iron supplementation is right for them.
• Vitamin B12: Deficiency of vitamin B12 can cause anemia and irreparable damage to the nervous system. Vegans (people who eat no animal products), including those who are pregnant, should take a daily vitamin B12 supplement. Low maternal vitamin B12 levels are more commonly seen in smokers and are associated with low birth weights and premature birth. The RDA of vitamin B12 for pregnant women is 2.6 mcg per day from all sources. Lactating women require 2.8 mcg per day.
• Vitamin B6: Women who have taken oral contraceptives during the months prior to pregnancy may be at increased risk of vitamin B6 deficiency. Vitamin B6 supplementation in the range of 10 to 25 mg three times per day has been reported to help relieve morning sickness.
• Iodine: Adequate iodine intake is needed for fetal development and maintaining pregnancy. A healthful diet that includes iodized salt should supply ample iodine, particularly if a prenatal multivitamin that contains iodine is taken. No additional supplementation should be necessary.
• Calcium: Calcium needs increase significantly during pregnancy. Low dietary intake of calcium is associated with increased risk of preeclampsia (a potentially serious complication involving high blood pressure and kidney problems). Most pregnant women should consume about 1,500 mg of calcium per day (total from food and supplements). Those at high risk for preeclampsia should consider taking up to 2,000 mg per day.
• Biotin: A deficiency of biotin (a B-complex vitamin) may occur in as many as 50% of pregnant women, and this deficiency may increase the risk of birth defects, according to one study. Taking 300 mcg per day can correct a biotin deficiency.
• Zinc: Women may become marginally zinc deficient during pregnancy, particularly if they are supplementing with greater than 30 mg per day of iron. Studies conflict as to whether zinc supplementation is effective or necessary in well-nourished pregnant women. Most prenatal multivitamins contain sufficient zinc to prevent a deficiency.
• Probiotics: Women who take supplemental Lactobacillus GG (a probiotic or “friendly” bacterium) during pregnancy and breast-feeding may help lower the risk of their child developing eczema, according to a one study. Not all probiotic supplements are equal, so particular attention should be given to obtaining a high-quality supplement of the right type.
• Vitamin C: Vitamin C requirements are increased in pregnancy. Women with low intakes of vitamin C before and during pregnancy have increased risk of preterm delivery and of preeclampsia compared with women taking higher amounts. The recommended amount is 500 to 1,000 mg per day.
What supplements should be avoided during pregnancy?
Supplements to avoid or use with caution during pregnancy include:
• Vitamin A: Women who are or could become pregnant have been told by doctors to take less than 10,000 IU per day of vitamin A to avoid the risk of birth defects. Although the evidence on which this recommendation is based has been contradicted by at least two studies, extremely large amounts of vitamin A do cause birth defects in experimental animals. The safe level for vitamin A supplementation in pregnant women is not known. Therefore, women who are pregnant should talk with a doctor before supplementing with more than 10,000 IU of vitamin A per day. This recommendation does not apply to beta-carotene.
• Vitamin D: Pregnant women need 400 IU of vitamin D per day. They should not exceed 1,000 IU per day unless supervised by a doctor.
• Supplemental hormones: Hormones sold as dietary supplements should be avoided during pregnancy, including androstenedione, melatonin, DHEA, human growth hormone, progesterone, and others, unless prescribed by a doctor.
• Untested supplements: Most newer and specialty nutrients have not been proven safe for use during pregnancy and should be avoided.
• Herbal supplements: Some herbs can be used safely in pregnancy and may even help with some pregnancy-related symptoms (for example, ginger tea or syrup may help with morning sickness, the nausea usually experienced in the first trimester). But because some have the potential for causing miscarriage or other serious problems, they should only be taken with consultation from an experienced and knowledgeable supervision.
Jeremy Appleton, ND, CNS, is a licensed naturopathic physician, certified nutrition specialist, and published author. Dr. Appleton was the Nutrition Department Chair at the National College of Naturopathic Medicine, has served on the faculty at Bastyr University of Natural Health Sciences, and is a former Healthnotes Senior Science Editor and a founding contributor to Healthnotes Newswire. He has worked extensively in scientific and regulatory affairs in the supplement industry and is now a consultant through his company Praxis Natural Products Consulting and Wellness Services.
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