Research Capsule

Study claim: L-carnitine supplementation in pregnancy in sufficient doses avoids a striking increase of plasma-free fatty acids, which are thought to be the main cause of insulin resistance and consequently gestational diabetes mellitus.

Published: Lohninger A, et al. Carnitine in pregnancy. Chemical Monthly 2005;136:1523-33.

Abstract: Gestational diabetes affects 5-10 per cent of pregnancies. By the 12th week of gestation, mean whole blood and plasma carnitine levels are already significantly lower than those of controls, with a further significant decrease up to parturition. On delivery, maternal plasma carnitine levels are decreased to about half of the concentrations seen in nonpregnant women. Diminished carnitine levels may cause a downregulation of carnitine palmitoyltransferase1 (CPT1), both the liver isoform (CPT1A) and muscle isoform (CPT1B), carnitine palmitoyltransferase2 (CPT2), and carnitine acetyltransferase (CRAT) in white blood cells of pregnant women, as determined by real time PCR using the LightCyclerSYBR Green technology. L-carnitine-L-tartrate supplementation of 2g/day resulted in an up to 10-fold increase of the relative mRNA abundances of CPT1B, CPT2 and OCTN2 and a five-fold increase of CPT1A and CRAT. There is a relationship between the relative mRNA levels of CPT1A and CPT1B and the free fatty acid plasma levels. The substitution of 2g L-carnitine-L-tartrate=d resulted in significantly lower free fatty acid levels compared to untreated controls and the groups substituted with 0.5g/day and 1g/day L-carnitine, although plasma carnitine levels were not significantly increased. The most substantial effect was the reduced portion of acylcarnitines on total carnitine in those women receiving 2g/day L-carnitine-L-tartrate. Carnitine substitution resulted in an enhanced excretion of both free carnitine and acylcarnitines, whereas acetylcarnitine accounts for 50-65 per cent of total acylcarnitines. Due to its excellent safety profile, L-Carnipure supplementation may be appropriate for pregnant women to restore their L-carnitine plasma levels and decrease plasma free fatty acids.

Potential applications: L-Carnipure tartrate consists of 68 per cent L-carnitine and 32 per cent L-tartaric acid. GRAS and kosher-certified, it is ideal for use in food and drink applications.

More info: +1 678 445 3535

Study claim: A natural metabolite of dehydropeiandrosterone (DHEA), 3-acetyl-7-oxodehydroepiandrosterone (7-oxo DHEA), when combined with a reduced-calorie diet and an exercise program, resulted in a significant weight loss compared with diet and exercise alone.

Published: Zenk JL, et al. Effect of lean system 7 on metabolic rate and body composition. Nutrition 2005 Feb; 21(2):179-85.

Abstract: This randomised, double-blind, placebo-controlled clinical trial evaluated whether a commercial weight-loss product (Lean System 7) would result in less reduction in resting metabolic rate (RMR) in overweight subjects on a calorie-restricted diet and exercise regimen than in subjects using diet and exercise alone. Forty-seven healthy overweight adults were given three capsules of a commercial weight-loss product twice daily or an identical placebo and followed a calorie-restricted diet and an exercise program for eight weeks. At baseline and week eight, researchers measured RMR, body weight, body mass index, waist and hip circumferences, and body composition by dual-energy X-ray absorptiometry. Of 47 adults enrolled, 35 completed the study. Subjects taking the weight-loss product had a significant increase in RMR, 7.2 per cent increase vs 0.7 per cent decrease in the placebo group. The treatment group also had a significant decrease in hip circumference, 3.78cm vs 2.07cm in placebo. There were no other statistically significant differences in any other outcome variable, diet composition, exercise compliance or adverse events. The product was well tolerated. In sum, the supplement produced greater weight loss than exercise alone, mostly from fat. It increased metabolism and weight loss without stimulants.

Potential applications: 7-Keto, an active ingredient in the Lean System 7 formulation, is sold as a dietary supplement under a wide range of labels.

More info: +1 952 937 7660

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