An independent human clinical trial involving 20 individuals showed particularly significant anti-adhesion properties of Cran Naturelle, an organic cranberry ingredient from Fruit d'Or Nutraceuticals, the world's largest organic cranberry producer that invests in clinical research and technology development.
The study involved 10 men and 10 women who were selected for their inability to produce anti-adhesion compounds in their urine unless they consume foods that contain phenolic compounds; hence, these subjects are more at risk of contracting urinary tract infections through the adhesion of E. coli, already within their bodies, to the linings of the urinary tract. The volunteers were given a special diet that contained no polyphenols and thus exhibited no anti-adhesion compounds in the urine. They were then given 1,000 mg of Cran Naturelle (a dose of two pills of 500 mg each), and had their urine tested 24 hours post-consumption.
The results were that 70 percent (14 out of 20) showed clear anti-adhesion activity in their urine within 24 hours of taking the cranberry supplement.
"Cran Naturelle is characterized by the presence of insoluble proanthocyanidins," says François Cormier, PhD, director of research and development at Fruit d'Or Nutraceuticals. "So, before conducting this study, the question we had was what was the metabolic activity of these proanthocyanidins once they were ingested. Would some component be released from this matrix to provide some physiological activity. The result was 'yes indeed.' The product, once consumed, elicited production of anti-adhesion compounds in the urine, which helps protect against colonization of E. coli.”
Stephen Lukawski, director of sales and marketing for Fruit d'Or Nutraceuticals, adds, "The conventional testing methods have all been designed for investigating soluble proanthocyanidins typically contained in cranberry juice powder. This research has reveals that insoluble proanthocyandin activity in the whole cranberry plays an important role in urological health."
Cormier adds that the next area of scientific investigation will likely focus on revealing the mechanism of action of cranberry insoluble proanthocyanidins and fiber in the intestinal environment, specifically interaction with and impact on gut flora, and to potentially discover prevention of E. coli adhesion or colonization within this biological ecosystem prior to E. coli migration to the urogenital tract. "We will explore whether or not insoluble proanthocyanidins contained within Cran Naturelle can inhibit invasion of uropathogenic E. coli in the intestines.”