Kyowa’s amino acid combo enhances NO bioavailability

Kyowa’s amino acid combo enhances NO bioavailability

Combination of L-Citrulline and L-Arginine caused a more rapid increase in plasma L-Arginine levels and marked enhancement of nitric oxide bioavailability than the single amino acids.

A combination of L-Citrulline and L-Arginine oral supplementation caused a more rapid increase in plasma L-Arginine levels and marked enhancement of nitric oxide bioavailability, including plasma cGMP (Cyclic guanosine monophosphate) concentrations, than with dosage with the single amino acids.

The study, published in Biochemical and Biophysical Research Communications, set out to determine the short-term action of oral doses of L-Citrulline and L-Arginine on nitric oxide production. Results showed that the combined supplementation was significantly more effective than single doses of arginine.

For more information about the BBRC-published study, click here.

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