Meta-analysis: Tonalin CLA May Help Reduce Fat Mass and Offer Long-Term Health Benefits Especially for Yo-Yo Dieters

La Grange, Ill. (May 23, 2007) – A new meta-analysis of human studies on the efficacy of conjugated linoleic acid (CLA) and body composition adds further evidence to the potential long-term health benefits of Tonalin® CLA.

According to the paper published in the American Journal of Clinical Nutrition1, 15 of the 18 clinical trials included in the meta-analysis used Tonalin® CLA. The research suggests that Tonalin® CLA could enhance overall health by effectively reducing body fat, and potentially preventing weight and fat regain commonly experienced by adults, especially yo-yo dieters. With rising numbers of overweight and obese Americans, it is becoming more evident that dieting alone doesn’t seem to help keep off lost pounds, as reported by UCLA researchers in a study recently published in American Pyschologist.2

The lead author of the CLA meta-analysis, Leah Whigham, Ph.D., from the University of Wisconsin School of Medicine and Public Health, concluded, “When the body of evidence is considered as a whole, CLA does have a beneficial effect on human body composition. Although this effect is modest, it could be important if accumulated over time, especially in an environment where continuous, gradual weight gain is the norm in the adult population."

After analyzing 18 eligible CLA studies that met their strict criteria (longitudinal randomized, double-blind, placebo-controlled human clinical trials using validated body composition measurements), Dr. Whigham and her colleagues concluded that among participants given 3.2 g a day, CLA produces a significant but modest reduction of fat mass of .2 pounds a week or .8 pounds a month compared to participants in the placebo group.

“This meta-analysis clearly indicated a dose response effect for CLA demonstrating that 3.2 grams of CLA daily produces a significant decrease in body fat mass,” said David Cai, Ph.D., senior scientist, Cognis Nutrition & Health. “The meta-analysis provides further scientific evidence that Tonalin® CLA can be a safe and effective option for people interested in improving and stabilizing their body composition. When taken as part of a healthy lifestyle, Tonalin® CLA could have the potential to help guard against the small, often cumulative weight gains that contribute to ‘weight creep’ over time. Research suggests that these cumulative fat and weight gains over the years as we age could pose high risks for chronic diseases, so early intervention is increasingly important.”

Dr. Cai explained that the meta-analysis helps to show why some clinical studies have failed to find a significant effect of CLA on body composition. According to the authors, these trials were too short in duration, did not have sufficient numbers of subjects, and lacked the statistical power to detect the difference in changes in body composition.

The meta-analysis includes findings of a landmark study by Dr. Jean-Michael Gaullier3. His research revealed that Tonalin® CLA not only reduced body fat mass in overweight adults by as much as 9 percent in one year, but also helped participants keep off the lost fat for a subsequent year during the follow-up trial.

Cognis’ Tonalin® CLA is derived from natural safflower oil, is stimulant-free, and is the most clinically tested CLA on the market. As the study authors pointed out, with regard to both safety and efficacy, CLA products enriched in both c9, t11, and t10, c12 isomers are preferable to those containing 4 isomers or single isomers. Tonalin® CLA meets high purity specifications in a 50:50 ratio of the two bioactive CLA isomers.

For more information about Tonalin® CLA or to place an order, visit, call 800.673.3702, e-mail [email protected], or fax 513.482.3576.

About Tonalin® CLA:

Tonalin® CLA is the original brand of CLA and is an exclusively licensed product of the Cognis Group. CLA is a polyunsaturated, conjugated fatty acid that is a natural part of the human diet, found primarily in meat and dairy products. Cognis produces Tonalin® CLA through a proprietary process that converts linoleic acid from safflowers into CLA, providing the highest quality of CLA available. Tonalin® CLA contains the lowest amount of non-naturally occurring isomers, a patent-protected attribute that provides food and dietary supplement manufacturers with the highest levels of ingredients known to be beneficial. Tonalin® CLA is available in several product forms—such as oil and water-dispersible powder—offering manufacturers a broad range of options for their products.

About Cognis:

Cognis ( is a worldwide supplier of innovative specialty chemicals and nutritional ingredients. The company employs about 8,000 people, and it operates production sites and service centers in 30 countries. Cognis has dedicated its activities to a high level of sustainability and delivers natural source raw materials and ingredients for food, nutrition and healthcare markets, and the cosmetics, detergents and cleaners industries. Another main focus is on products for a number of other industries, such as coatings and inks, lubricants, textiles, as well as agriculture and mining. The company holds a 50-percent stake in the joint venture Cognis Oleochemicals, one of the world’s leading manufacturers of natural-source oleochemical basestocks. Cognis is owned by private equity funds advised by Permira, GS Capital Partners, and SV Life Sciences. In 2006, Cognis recorded sales of 3.37 billion euros and an Adjusted EBITDA (operating result) of 394 million euros.

1. Leah D Whigham, Abigail C Watras, Dale Schoeller. Efficacy of conjugated linoleic acid for reducing fat mass: a meta-analysis in humans. Am. J. Clin. Nutr. 2007;85:1203-11

2. Mann T, Tomiyama AJ, Westling E, Lew AM, Samuels B, Chatman J. Medicare's Search for Effective Obesity Treatments: Diets Are Not the Answer. Am Psychol. 2007 Apr;62(3):220-33

3. Gaullier, J-M et al J. Nutr. 2005 135:778-784

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