Theravalues, a leading Japan-based biomedical venture firm, announced that three clinical trials conducted by a group of researchers at the University of Tsukuba, discovered that regular intake of Theracurmin™, an enhanced form of curcumin that allows for greater absorption, has positive impact on central blood pressure, arterial compliance and vascular endothelial function. Improvements in these functions highlight curcumin’s phenomenal power to alleviate and improve arterial stiffness for the postmenopausal women.
Three studies were conducted on 32 to 51 healthy postmenopausal women in Japan in 2012. Past studies have shown that women after menopause experience an increased risk of heart disease due to the withdrawal of natural estrogen, a hormone that is produced throughout premenopause term that prevents the production of bad cholesterol (LDL) while sustaining the level of good cholesterol (HDL).
In the most recently conducted study, published in the March 2013 edition of ARTERY Research, The official journal of the Association for Research into Arterial Structure, and Physiology (ARTERY), the group led by Dr. Seiji Maeda, Faculty of Health and Sport Sciences at the Center for Tsukuba Advanced Research Alliance, University of Tsukuba, examined the arterial compliance of 51 healthy postmenopausal women. The women were divided into four groups: 12 taking placebo; 13 taking both placebo and aerobic exercise; 12 taking Theracurmin only; and 14 taking both Theracurmin and aerobic exercise. After an eight-week trial, the group that performed aerobic exercise and took Theracurmin showed a significant improvement in the average carotid arterial compliance while that of the placebo group remained unchanged.
“The results of the trial were consistent with the two preceding pilot studies, which demonstrated the efficacy of curcumin on central arterial with hemodynamic and vascular endothelial functions of the postmenopausal women, respectively,” said Dr. Maeda. All the studies are double-blind, randomized and placebo controlled.
Curcumin, a polyphenol derived from turmeric (Curcuma longa L), is known to have a range of pharmacological properties, including antioxidant and anti-inflammatory. However, its low bioavailability due to low oral absorption has limited its clinical applicability. The submicron granularity and surface processing technology developed by Theravalues has succeeded in enhancing its body absorption by more than 27 times compared to that of conventional curcumin powder.