Evidence-based Products

StudyClaim: Using a DNA fingerprinting technique, Pure World?s black cohosh (Actaea racemosa) is positively identified.

Published: Zerega N, et al. Using amplified fragment length polymorphisms to identify black cohosh (Actaea racemosa). Economic Botany 2002; 56(2):154-64.

Abstract: The rhizome of black cohosh is a popular botanical used for female health concerns. The rhizomes used in black cohosh products are often collected from the wild; correct identification is therefore crucial. This paper examines the use of the DNA fingerprinting technique, AFLP, as a means of identifying A. racemosa from three closely related sympatric species. To this end, 262 AFLP markers were generated, and one unique fingerprint was identified for A. racemosa, whereas two, six and eight unique fingerprints were identified for the related species A. pachypoda, A. cordifolia and A. podocarpa, respectively. This suggests AFLP analysis may be a useful method for quality control.

Potential Applications: Use of this uncommon assay will aid quality-control efforts of botanicals.

More info: Tel: + 1 201 440 5000

Study Claim: BSP 201, based on a fraction of sheanut oil, demonstrates anti-inflammatory activity.

Published: Takada Y, Aggarwal BB. Betulinic acid suppresses carcinogen-induced NF-kappa B activation through inhibition of I kappa B alpha kinase and p65 phosphorylation: abrogation of cyclooxygenase-2 and matrix metalloprotease-9. J Immunol 2003 Sep 15; 171(6):3278-86.

Abstract: Betulinic acid (BA), a pentacyclic triterpene from the bark of the white birch tree, has been reported to be a selective inducer of apoptosis in tumor cells. It exhibits anti-inflammatory and immuno-modulatory properties. Because of the critical role of transcription factor NF-kappaB in growth modulatory, inflammatory and immune responses, researchers postulated BA modulates the activity of this factor.

The team investigated the effect of BA on NF-kappaB and NF-kappaB-regulated gene expression activated by carcinogenic agents. BA suppressed NF-kappaB activation induced by TNF, PMA, cigarette smoke, okadaic acid, IL-1 and H(2)O(2). BA suppressed the activation of IkappaBalpha kinase. BA inhibited NF-kappaB activated by TNFR 1, TNFR-associated death domain, TNFR-associated factor 2, NF-kappaB-inducing kinase and IkappaBalpha kinase. Treatment of cells with this triterpinoid also suppressed NF-kappaB-dependent reporter gene expression and the production of NF-kappaB-regulated gene products.

Potential applications: BSP 201 can help sore joints and muscles, and arthritis.

More info: Tel: + 45 8730 6293

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