Natreon, offering a wide range of scientifically proven Ayurvedic products, has announced a Murray State University study evaluating therapeutic efficacy and safety of Crominex 3+, a complex of trivalent chromium, Capros Phyllanthus emblica extract and PrimaVie Purified Shilajit in moderately arthritic dogs.
According to Dr. Sanni Raju, Natreon CEO, study findings revealed dogs receiving Crominex 3+ (1000 μg chromium, 15 mg Phyllanthus emblica extract and 15 mg purified Shilajit per day in two divided doses) exhibited a significant (P<0.05) reduction in arthritic pain noted as early as after 90 days with a maximum reduction after 150 days of treatment. Pain level remained the same or slightly increased in the dogs receiving placebo. No significant change occurred in physical parameters or serum biomarkers in dogs on placebo or Crominex 3+, which suggested that Crominex 3+ was well tolerated by arthritic dogs.
In conclusion, Crominex 3+ significantly (P<0.05) ameliorated arthritic pain and improved quality of life without causing any untoward effects in moderately arthritic dogs.
In a randomized, double-blind, placebo-controlled study, 11 moderately arthritic dogs received placebo or Crominex 3+ twice daily for a period of 150 days. On a monthly basis, each dog was evaluated for arthritis associated pain (overall pain, pain upon limb manipulation and pain after physical exertion) and a full physical exam (body weight, body temperature and heart rate) was conducted. At the same time intervals, serum samples were examined for biomarkers of kidney (BUN and creatinine), liver (bilirubin, ALT and AST) and heart and skeletal muscle (CK) functions.
In Crominex 3+ treated dogs, overall pain was reduced from 6.00±0.50 observed on day 0 to 3.11±0.31 on day 90 and 1.55±0.18 on day 150, level of pain upon limb manipulation was reduced by day 90 (1.58±0.17) with a maximum reduction on day 150 (0.78±0.08) compared to day 0 (2.50±0.14), and the pain after physical exertion was reduced by day 90 (0.83±0.19) and marked reduction in pain by day 150 (0.42±0.14) compared to day 0 (1.81±0.18). All the results were significant (P<0.05). Dogs receiving a placebo showed no significant change.
Crominex 3+ complex‚ with standardized extract of Indian gooseberry and a proprietary form of the adaptogen Shilajit helps to support normal cellular glucose absorption‚ healthy endothelial function‚ healthy lipid and triglyceride levels‚ and normal cellular energy production, and as far as we know, Crominex 3+ is the first chromium supplement to also have anti-arthritic activity”, says Dr. Raju.
Capros is a patented, clinically researched nutritional supplement ingredient developed to provide significant and superior cardiovascular benefits. A highly standardized extract of the edible antioxidant superfruit Phyllanthus emblica, or Indian gooseberry, Capros is considered the ultimate superfruit extract developed for cardiovascular health
PrimaVie Shilajit improves bioavailability of metal ions and is an energy and testosterone booster with cardiovascular, blood glucose and anti-arthritic health benefits and is an excellent ingredient for sports nutrition.