Cactus Botanics Refines Mangosteen Extract Offering Based on Study of Alpha-mangostin Activity

Research published in J Agric Food Chem (2006 Mar 22;54(6):2077-82) entitled " Antioxidant Xanthones from the pericarp of Garcinia mangostana (Mangosteen)" involved the separation, identification and elucidation of the structure of two new highly oxygenated prenylated xanthones, 8-hydroxycudraxanthone G and mangostingone [7-methoxy-2-(3-methyl-2-butenyl)-8-(3-methyl-2-oxo-3-butenyl)-1,3,6-trihydroxyxanthone, together with 12 known xanthones, cudraxanthone G, 8-deoxygartanin, garcimangosone B, garcinone D, garcinone E, gartanin, 1-isomangostin, alpha-mangostin, gamma-mangostin, mangostinone, smeathxanthone A, and tovophyllin A from the pericarp of Garcinia mangostana (Mangosteen).

The researchers determined the antioxidant activities of all the isolates, using authentic and morpholinosydnonimine-derived peroxynitrite methods, finding highest antioxidant activities for alpha-mangostin, gamma-mangostin, mangostinone and smeathxanthone A. The researchers went on to note that "Alpha-mangostin inhibited 7,12-dimethylbenz[alpha]anthracene-induced preneoplastic lesions in a mouse mammary organ culture assay with an IC50 of 1.0 microg/mL (2.44 microM)."(1)

Cactus Botanics, in its ongoing efforts to provide the most effective and standardized products possible, has determined between its marketing and production teams, that it is possible to produce a range of mangosteen extract products and has confirmed that it will, in fact do so, as a response to market needs, ongoing research and trials and customer requests. The proposed specification range the company will provide will be from Alpha-mangostin 10%, 25% to 50%.

Those interested in these products are welcome to contact Cactus for detailed information:
Email: [email protected]

(1)Abstract on PubMed:

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