L-citrulline self-affirmed GRAS

L-citrulline self-affirmed GRAS

Kyowa Hakko USA has completed GRAS self-affirmation for the valuable amino acid.

Kyowa Hakko USA Inc., the wholly owned subsidiary of Kyowa Hakko Bio Co. Ltd., has announced it has completed GRAS (generally recognized as safe) self-affirmation for the valuable amino acid L-citrulline.

L-citrulline is an amino acid that plays an important role in nitric oxide (NO) metabolism and regulation. L-citrulline is converted to L-arginine in the body to support L-arginine and NO levels. Increased production of NO promotes vascular dilation which improves oxygen and blood circulation throughout the body. L-citrulline is also expected to relieve muscle fatigue through ammonia elimination. Antioxidant action and heart protection are also known.

“We are extremely proud to announce GRAS for our amino acid L-citrulline, and look forward to working with manufactures to incorporate it into foods and beverages,” said Dr. Toshikazu Kamiya, president and CEO of Kyowa Hakko USA.

L-citrulline is preservative-free, allergen-free, and contains no artificial flavors or colors. Manufactured in the U.S. using a proprietary fermentation process, L-citrulline is an ultra-pure amino acid that carries the Kyowa Quality logo, ensuring that this ingredient is backed by our commitment to the highest manufacturing standards.

L-citrulline will be marketed by Kyowa Hakko USA as a food ingredient in the United States for use at levels of 275 mg of L-citrulline/serving up to a maximum of 2,000 mg/day in various food products, such as beverages and beverages bases; grain products and pastas; and milk products.

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