Published: Kelley DS, et al. Docosahexaenoic acid supplementation improves fasting and postprandial lipid profiles in hypertriglyceridemic men. Am J Clin Nutr 2007 Aug;86(2):324-33.
Abstract: The effects of docosahexaenoic acid (DHA) on the mean size and concentrations of VLDL, LDL and HDL cholesterol subclasses have not been previously studied. Researchers sought to determine the effects of DHA supplementation on the concentrations of apoproteins; large, medium and small VLDL, LDL and HDL particles; and the mean diameters of these particles in fasting and postprandial plasma.
Hypertriglyceridaemic men aged 39-66 yers (n=34) participated in a double-blind, randomised, placebo-controlled parallel study. They received no supplements for the first eight days and received either 7.5g DHA oil/day (3g DHA/day) or olive oil (placebo) for the last 90 days.
DHA supplementation for 45 days significantly decreased concentrations of fasting triacylglycerol (24 per cent), large VLDL (92 per cent), and intermediate-density lipoproteins (53 per cent) and the mean diameter of VLDL particles (11.1nm). It elevated concentrations of LDL cholesterol (12.6 per cent), small VLDL particles (133 per cent), and large LDL particles (120 per cent) and the mean diameter of LDL particles (0.6nm) in fasting plasma. Similar changes were observed for the area under the curve for postprandial samples (0 to six hours); however, the number of small dense LDL particles decreased significantly (21 per cent), and the change in LDL cholesterol was not significant. Continued supplementation with DHA beyond 45 days caused no further changes; placebo treatment altered none of the responses tested.
DHA supplementation may improve cardiovascular health by lowering concentrations of triacylglycerols and small, dense LDL particles.
Potential applications: life'sDHA is a sustainable and vegetarian source of the omega-3 fatty acid DHA for use in foods, beverages; infant formula; and supplements to support brain, eye and cardiovascular health throughout life.
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Study claim: Svetol works as a fat burner to reduce body mass index and increase the lean mass to fat mass ratio, by decreasing the glucose intestinal absorption and by inhibiting the glucose-6-phosphatase (G-6-Pase) in the liver.
Published: Nardon K, et al. Green-coffee extract Svetol can manage weight: a review. AgroFOOD industry hi-tech 2007;18(5-Supplement):37-9.
Abstract: This review presents the different works investigated on Svetol, a green coffee-bean extract rich in chlorogenic acids with a specific ratio between 5-caffeoylquinic acid and other caffeoylquinic acid isomers, in terms of efficacy on weight management and mechanism of action. The two clinical trials indicated a significant decrease (vs placebo group) of weight after 60 days of 400mg daily supplementation and a significant decrease of post-load glycaemia compared to the one obtained before supplementation.
A complementary in vitro study showed that Svetol inhibits the glucose-6-phosphatase (G-6-Pase), a hepatic enzyme involved in the glucose release in the bloodstream. Thus, Svetol can reduce weight in humans by regulating the blood sugar concentration via an action on the G-6-Pase.
Potential applications: In the weight-management sector, Svetol can be used in supplements as well as beverages and soups.
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