Antioxidant and antitumor effects of hydroxymatairesinol
(HM-3000, HMR), a lignan isolated from the knots of spruce.
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Kangas L, Saarinen N, Mutanen M, Ahotupa M, Hirsinummi R, Unkila M, Perala M, Soininen P, Laatikainen R, Korte H, Santti R.
Hormos Nutraceutical Ltd, Turku, Finland.
The antioxidant properties of hydroxymatairesinol (HM-3000) were studied in vitro in lipid peroxidation, superoxide and peroxyl radical scavenging, and LDL-oxidation models in comparison with the known synthetic antioxidants Trolox (a water-soluble vitamin E derivative), butylated hydroxyanisol (BHA) and butylated hydroxytoluene (BHT). On a molar basis HM-3000 was a more effective antioxidant than Trolox in all assays and more effective than BHT or BHA in . . .