AUSTIN, Texas--May 14, 2003--Applied Food Sciences, LLC (AFS(TM)) announced that its Green Coffee Antioxidant (GCA(TM)) product derived from green coffee beans contains 55 percent pure chlorogenic acid. Research shows that chlorogenic acid has significant health benefits including a potential role in weight management.
Chlorogenic acid has been proven in animal studies in vitro to inhibit the hydrolysis of the glucose-6-phosphate enzyme in an irreversible fashion. This mechanism allows chlorogenic acid to reduce hepatic glycogenolysis (transformation of glycogen into glucose) and to reduce the absorption of new glucose. In addition, in vivo studies on animal subjects have demonstrated that the administration of chlorogenic acid lessens the hyperglycemic peak resulting from the glycogenolysis brought about by the administering of glucagen, a hyperglycemiant hormone. The studies also confirmed a reduction in blood glucose levels and an increase in the intrahepatic concentrations of glucose-6-phosphate and of glycogen (Herling A.W., Am J Physiol 1998, 274 G1087-93 and Simon, C. Arch Biochem Biophys, 2000, 373 (2) 418-28).
In a human clinical study done in Moscow at the Modern Medical Center on 75 healthy volunteers, each of whom received either 90 mg/d of chlorogenic acid or a placebo prior to the test meal, results indicated the chlorogenic acid group had lowered the increase in blood glucose level between 15-20 percent (Abidoff MT, 1999 Moscow Center for Modern Medicine, Russian Ministry for National Defense Industries, Clinical Report p12.).
"We realize that weight management is an important part of overall health and nutrition in the functional foods category," stated Chris Fields, AFS technical director. "Creating ingredients food and beverage manufacturers can utilize to increase the nutritional functionality of their existing brands without impacting the overall sensory characteristics is something we strive for at AFS."
In addition, a recently published paper describes chlorogenic acid's potential role in the management of diabetes. This cohort study evaluated coffee consumption and the risk of type 2 diabetes mellitus in a relatively large Dutch population. Coffee happens to be one of the primary sources of chlorogenic acid in the human diet. Higher coffee consumption was associated with a lower risk of type 2 diabetes, even after adjustments were made for potential cofounders. Furthermore, the risk of type 2 diabetes decreased with higher coffee consumption (Van Dam, et al, 2002 The Lancet 360:1477-78).
According to Loretta Zapp, AFS chief executive officer, "GCA alone or in combination with other science-based weight loss ingredients such as chromium and conjugated linoleic acid can provide a means beverage formulators may utilize to create products specifically targeted to those individuals trying to lose or manage their weight."
Applied Food Sciences, LLC (AFS(TM)), based in Austin, specializes in the development and marketing of proprietary technologies used in foods, beverages and nutritional supplements. Currently AFS is most well known for its patented CDG(TM) (Calcium D-Glucarate), Preventium (R)(Potassium Hydrogen Glucarate) GCA(TM) (Green Coffee Antioxidant) and HealthyRoast(TM). HealthyRoast is a technology utilized by coffee roasters that significantly boosts natural antioxidant levels in brewed coffee. CDG and Preventium are patented dietary supplement ingredients that are sold in bulk to companies such as GNC, Rexall, Schiff, Enzymatic Therapy, Solaray and Natrol. AFS' revolutionary products have been featured on television and in publications such as CNN, NBC, MSNBC, USA Today, Parade, Muscle and Fitness, FLEX, Prevention and Newsweek.