Changsha Nutramax Inc. promotes new product Hordenine 98% from Hordeum vulgare

IUPAC name 4-(2-dimethylaminoethyl)phenol
Other names N,N-Dimethyltyramine
CAS number [3595-05-9]
PubChem 68313
Molecular formula C10H15NO
Molar mass 165.23 g mol-1
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references
Hordenine (N,N-dimethyltyramine) is a phenylethylamine alkaloid which stimulates the release of norepinephrine in higher animals.

Occurrence in nature
Peyote (Lophophora williamsii), San Pedro cactus (Echinopsis pachanoi), and Peruvian Torch cactus (Echinopsis peruviana) all produce high levels of this compound. These cacti also produce high levels of mescaline and other phenylethylamine compounds.

Cacti in the genus Ariocarpus, Opuntia, Pereskia, and Coryphantha also produce these alkaloids, though not in high concentrations.

Aztekium also contains it.
Hordenine is an ingredient of some plants used as feed for animals, such as sprouted barley and certain grasses. Hordenine is an indirectly acting adrenergic substance available without a prescription. Hordenine is known as N,N-dimethyltyramine.

Hordenine supplement use
Hordenine has been promoted as a weight loss agent with the claim that it stimulates the central nervous system.

Hordenine Research
Phenylalkylamine alkaloids from Stapelia hirsuta L.
Nat Prod Res. 2006 Jul 10;20(8):710-4. Department of Pharmacognosy, College of Pharmacy, Cairo University, Cairo, Egypt.
Four alkaloids of the phenethylamine derivatives have been isolated from the n-butanol fraction of the aerial parts of Stapelia hirsuta L. The structures of the isolated alkaloids were determined as N-acetyl hordenine (a new natural compound), hordenine, candicine and hordenine -1-O-beta-D-glucoside, in addition to luteolin-7-O-beta-D-glucopyranoside.

Pharmacological effects of hordenine
Dtsch Tierarztl Wochenschr. 1995 Jun;102(6):228-32. Institut fur Pharmakologie, Toxikologie und Pharmazie, Tierarztlichen Hochschule Hannover.
After ingestion of plants with hordenine may be detected in blood or urine of horses. Hordenine liberates norepinephrine from stores. In isolated organs and those structures with reduced epinephrine contents the hordenine effect is only very poor. Experiments in intact animals (rats, dogs) show that hordenine has a positive inotropic effect upon the heart, increases systolic and diastolic blood pressure, peripheral blood flow volume, inhibits gut movements but has no effect upon the psychomotorical behaviour of mice. All effects are short and only possible after high doses which are not to be expected after ingestion of hordenine containing feed for horses. A measurable increase of the performance of racing horses is quite improbable.

Hordenine: pharmacology, pharmacokinetics and behavioural effects in the horse.
Equine Vet J. 1990 Nov;22(6):437-41. Kentucky Equine Drug Research Program, Graduate Center in Toxicology, University of Kentucky, Lexington
We investigated the pharmacological actions of hordenine in the horse. Hordenine (2.0 mg/kg bodyweight [bwt]) was administered by rapid intravenous (iv) injection to 10 horses. Typically, dosed horses showed a flehmen response and defecated within 60 seconds. All horses showed substantial respiratory distress. Respiratory rates increased about 250 per cent and heart rates were approximately double that of resting values. All animals broke out in a sweat shortly after iv injection, but basal body temperature was not affected. These effects were transient, and the animals appeared normal within 30 minuntes of dosing. Treated horses were tested in a variable interval responding apparatus 30 mins after dosing and no residual stimulation or depressant effects of hordenine were apparent. Animals dosed orally with 2.0 mg/kg bwt of hordenine showed no changes in heart rate, respiratory rate, basal body temperature or behaviour. After iv injection of hordenine, (2.0 mg/kg bwt) plasma reached a maximum value of about 1.0 micrograms/ml, and declined thereafter in a biexponential fashion.

About Changsha Nutramax Inc.:
Changsha Nutramax Inc., is Leading manufacturer and exporter of Botanical Extracts in China, we do all for dedicated to the identification, development and production of active ingredients from Chinese herb, for use in the pharmaceutical, health-food and cosmetics industries.

Changsha Nutramax Inc., a privately owned 3 factory for producing botanical extracts, with around 850 employees, including 10% professors dedicated to full-time research, manages cultivation, manufacturing.

Our major standardized product, such as Blueberry P.E. 25% Anthocyanidins, Grape Seed Extract 95% OPC, Green Tea Extract 60% EGCG, Luo Han Guo Extract 80% Mogrosides, and Effective Component Monomer prouct such as 5-HTP, Resveratrol 99%, Huperzine A 99%, Paclitaxel 99%, Synephrine 99%, and so on.....our products is well sale more than 30 countries throughout the world.

NUTRAMAX’s other leading Products
No. Leading Products Specification
1 Luo Han Guo Extract 80% Mrogosides
2 Blueberry P.E. 25% Anthocyanidins
3 Resveratrol 20%~99%
4 Flax Seed P.E. 20%~80% SDG
5 5-HTP 98% 5-HTP
6 Green Tea Extract 95% Polyphenols
7 Rhodiola Rosae P.E. 3% Rosavins/1% Salidroside
8 Reishi Mushroom 30% Polysacchrides
9 Magnolia Bark P.E. 40% Honokiol+50%Magnolol
10 Red Clover P.E. 8%~40% Isoflavones
11 Kindey Bean Extract 1% Phaseolamin
12 Banaba Leaf P.E. 1%~10% Corosolic Acid
13 Epimedium Extract 10%~50% Icariins
14 Cinnamon Extract 20:1
15 Cassia Nomame P.E. 8%~60% Dimer Flavans
16 Gynostemma pentaphyllum P.E. 85% Gypenoside
17 Sesamine 30%, 60%, 90% Sesamine
18 Grape Seed P.E. 95% OPC

Contact information:
Company: Changsha Nutramax Inc.
FDA Registration Number: 15970949816
Add.: F25,Jiahege BLDG, #217 Wanjiali Road,Changsha,China, 410016
Telephone: 86-731-2939658
Mobile: +86-13874928210
Fax number: 86-731-2938822
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