Clinical Pearls Feature - Week of August 26 (Acne-Vitamin C, Cancer-Prostate,Isoflavone,Soy)

ACNE - Vitamin C - In a study of 89 individuals completing a 12-week trial, 37 subjects applied a vitamin C derivative as sodium L-ascorbyl-2-phosphate 5% lotion compared with 35 subjects who applied a clindamycin phosphate 1% lotion and 17 who applied a vehicle lotion, twice daily, after washing their faces. The improvement was 75.7% in those applying the vitamin C derivative compared with 62.9% for the clindamycin and 17.6% for the vehicle lotion. This form of vitamin C is a stable derivative of vitamin C, is well absorbed into the dermis, is converted into vitamin C at the cell membrane and is continuously taken into the cell. Tissue damage is inhibited because the vitamin C derivative has an antiinflammatory action and prevents acne scarring. “Vitamin C Derivative Cleared More Acne Than Clindamycin 1%,” McNamara D, Skin and Allergy News, July 2003:36. 40758

CANCER - Prostate, Isoflavone, Soy - In a study of 133 cases of prostate cancer and 265 matched controls who were between 50 and 89 years of age who were evaluated over a 3-year period, the risk of prostate cancer comparing the highest tertile of tofu intake versus the lowest was 0.58. There was a statistically significant association between the highest quartile of intake of soy foods and genistein with the lowest quartiles. There was a reduced risk with the intake of daidzein as well. The mean intake of tofu for the cases was 26.9 g/day, combined soy foods 70.1 g/day, genistein 40.7 mg/day and daidzein 24.0 mg/day. The mean intake of tofu for the controls was 31.3 g/day, combined soy foods 83.8 g/day, genistein 47.9 mg/day and daidzein 27.8 mg/day. “Soy and Isoflavone Consumption in Relation to Prostate Cancer Risk in China,” Lee MM, Gomez SL, et al, Cancer Epidemiol Biomarkers Prev, July 2003;12:665-668. (Address: Marion M. Lee, (FAX) (415) 476-6014, E-mail: [email protected]) 40753

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