Clinical Study Examines Iceland Health Chromax Chromium Picolinate for Hunger Food Intake and Craving Reduction

Nutrition 21, Inc. (Nasdaq: NXXI), the developer and marketer of nutritional supplements under the Iceland Health® and Diabetes Essentials® brands, reported today that results of a randomized, double-blind, placebo-controlled clinical study published online in Diabetes Technology & Therapeutics showed that Nutrition 21’s Chromax® chromium picolinate significantly reduced hunger levels by 24%, food intake by 25%, and also reduced cravings for high-fat foods in adult non-diabetic overweight women. The study was conducted by researchers at the Pennington Biomedical Research Center, the largest academically based nutrition research center in the world.

“Study subjects were allowed to eat any type and amount of food throughout the study. The participants who received chromium picolinate reduced their caloric intake by an average of 365 calories per day between their baseline and final (week 8) visit,” stated Dr. Steve Anton, investigator and lead author of the publication.

The randomized, double-blind, placebo-controlled, 8-week study, entitled “Effects of Chromium Picolinate on Food Intake and Satiety,” was published online in Diabetes Technology & Therapeutics (, and is scheduled to be released in the October 2008 print issue of the journal. The study population comprised 42 overweight adult women who reported craving carbohydrates. Subjects were administered either Chromax chromium picolinate capsules (containing 1,000 mcg chromium) or matching placebo capsules for 8 weeks. Food intake was directly measured at the research center’s eating laboratory at baseline, after 1 week and again after 8 weeks.

About Pennington Biomedical Research Center
The Pennington Biomedical Research Center mission is to promote healthier lives through research and education in nutrition and preventive medicine. The Center is a campus of the Louisiana State University System and conducts basic, clinical and population research. The research enterprise at the Center includes 80 faculty and more than 40 post-doctoral fellows who comprise a network of 50 laboratories supported by lab technicians, nurses, dieticians, and support personnel, and 19 highly specialized core service facilities. The Center's nearly 600 employees occupy several buildings on the 234-acre campus.

About Nutrition 21
Nutrition 21, Inc. (NASDAQ: NXXI), headquartered in Purchase, NY, is a nutritional bioscience company and the maker of chromium picolinate-based and omega-3 fish oil-based supplements with health benefits substantiated by clinical research. Nutrition 21 holds more than 30 patents for nutrition products and uses. Nutrition 21’s portfolio of health and wellness products include: Iceland Health Chromax®, Iceland Health Life Advanced Memory Formula™, Diabetes Essentials, Iceland Health® Maximum Strength Omega-3 and Iceland Health® Joint Relief. The company also manufactures private label supplements and ingredients for third parties. Nutrition 21 distributes its products nationally through more than 29,000 major food, drug and super center stores throughout the United States and internationally. For more information please visit

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This press release may contain certain forward-looking statements. The words “believe,” “expect,” “anticipate” and other similar expressions generally identify forward-looking statements. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of their dates. These forward-looking statements are based largely on the Company's current expectations and are subject to a number of risks and uncertainties, including without limitation: the effect of the expiration of patents; regulatory issues; uncertainty in the outcomes of clinical trials; changes in external market factors; changes in the Company's business or growth strategy or an inability to execute its strategy due to changes in its industry or the economy generally; the emergence of new or growing competitors; various other competitive factors; and other risks and uncertainties indicated from time to time in the Company's filings with the Securities and Exchange Commission, including its Form 10-K/A for the year ended June 30, 2007. Actual results could differ materially from the results referred to in the forward-looking statements. In light of these risks and uncertainties, there can be no assurance that the results referred to in the forward-looking statements contained in this press release will in fact occur. Additionally, the Company makes no commitment to disclose any revisions to forward-looking statements, or any facts, events or circumstances after the date hereof that may bear upon forward-looking statements.

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