Clinical Study Shows Hyaluronic Acid in Biocell Collagen II Found To Have Significant Absorption and Bioavailability

NEWPORT BEACH, Ca., February 3, 2004– BioCell Technology LLC, the exclusive suppliers of the Patented BioCell Collagen II® ingredient, released results from a double blind clinical study proving that the naturally occurring Hyaluronic Acid (HA) in the BioCell Collagen II® product has significant peak absorption and steady state bioavailability in normal volunteer subjects. Dr. William Judy, senior scientist at SIBR Research, called the study “groundbreaking science” and noted BioCell Technology’s revolutionary form of a reduced molecular weight HA manufactured using patented technology, is absorbed and is therefore readily available for use by the body. This is in contrast to previous published studies which showed that other HA forms were not absorbed and thus unavailable for use by the human body,

In a 36-hour peak absorption study using a single dose, BioCell Collagen II® HA significantly increased in the blood in four hours and peaked at a level 7008.62% above control in twelve (12) hours (P≤0.05). In the blood, HA was rapidly metabolized to two metabolites 1/600th the size of the ingested HA.

In a 28-day steady state bioavailability study using a constant daily dose, after seven (7) days, BioCell Collagen II® HA and its metabolites in the blood became stable, and these metabolites remained significantly increased (p≤0.001) throughout the balance of the study (HA at 3542.58% above control and HA metabolite at 11890.15% above control).

“This unprecedented study on hyaluronic acid, a key element in the unique matrix of BioCell Collagen II® which consists of Collagen Type II, Chondroitin Sulfate, and Hyaluronic Acid, demonstrates a synergistic effect that allows for the impressive absorption as indicated in these exciting and promising studies. BioCell Technology has expanded its intellectual property profile and has a patent pending to cover oral and topical applications of hyaluronic acid derived from various natural sources for use in dietary supplements and cosmetics,” said Suhail Ishaq, Vice President of BioCell Technology, LLC.

By determining the rate and magnitude of HA absorption and its bioavailability, this study using the BioCell Collagen II® product clearly demonstrates that this HA form has the physical characteristics necessary to allow it and its metabolites to move rapidly from the blood to the tissues. These findings further support the previous documented efficacy of BioCell Collagen II® in the management of joint and skin care.


Founded in 1997, BioCell Technology, LLC pioneered the applications of Sternum Collagen Type II, the highest concentrated natural source available of type II collagen. It is the exclusive supplier of BioCell Collagen II™. BioCell Technology, LLC owns the exclusive rights to market BioCell Collagen II under the United States Patent #6,025,327. BioCell Collagen II™ is a branded trademarked logo that is available for display on its client’s labels to market under their own brand name or formulas. For more information on BioCell Collagen II, please contact the BioCell Technology sales office at (949) 476-3786, or visit them at

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