Recent studies in animal models have suggested that curcumin can lower blood lipids, including total cholesterol. This study was undertaken to determine the lipid-lowering effects of curcumin in obese humans. Thirty subjects were enrolled in this randomized, double-blind crossover trial and were given "C3 Complex capsules" containing 500 mg curcuminoids and 5 mg of a black pepper extract contain 95 percent piperine, a well-known bioavailability enhancer. The dosage was 1-gram curcuminoids, or placebo, daily for 30 days. After a washout of two weeks, the treatments were switched so each person took the active and the placebo by the end of the trial. The researchers were able to determine that this curcumin supplementation significantly reduced serum triglycerides but did not significantly affect total, low, or high-density cholesterol levels. The authors recommended that larger-scale trials are needed to better understand the effects of curcumin on human lipid profiles.
May 21, 2012. DOI: 10.1002/ptr.4715
Effects of Supplementation with Curcuminoids on Dyslipidemia in Obese Patients: A Randomized Crossover Trial
Dyslipidemia is a leading risk factor for cardiovascular disease and is also a common feature of obesity. Curcumin is a bioactive phytochemical with well-known antioxidant, anti-inflammatory, and cardioprotective properties. The present study investigated the hypolipidemic activity of curcumin in obese individuals.
Participants were treated with curcuminoids, or placebo in a randomized, double-blind, placebo-controlled, crossover trial. Serum concentrations of total cholesterol, triglycerides, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol, together with anthropometric parameters and high-sensitivity C-reactive protein were measured before and after each treatment period.
Anthropometric parameters including weight, BMI, waist circumference, hip circumference, arm circumference, and body fat remained statistically unchanged by the end of trial. As for the lipid profile parameters, serum triglycerides were significantly reduced following curcumin supplementation. However, curcuminoids were not found to affect serum levels of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and high-sensitivity C-reactive protein.
In summary, the findings of the present study indicated that curcuminoid supplementation leads to a significant reduction in serum triglycerides concentrations but do not have a significant influence on other lipid profile parameters as well as body mass index and body fat.