According to an analysis reported in the June issue of Journal of the National Cancer Institute (Vol. 96, No. 12, 921-925, June 16, 2004), using patients from the Calcium Polyp Prevention Study, a randomized, double-blind, placebo-controlled chemoprevention trial among patients with a recent colorectal adenoma, results suggest that calcium supplementation may have a more pronounced effect on advanced colorectal lesions than on other types of polyps. (Calcium use reduced the risk of all polyps by 14 percent and the risk of advanced polyps by 35 percent. ) The researchers also noted that "the effect of calcium supplementation on adenoma risk was most pronounced among individuals with high dietary intakes of calcium and fiber and with low intake of fat, but the interactions were not statistically significant."