Effect of Folate and Mecobalamin on Hip Fractures in Patients With Stroke

Japanese research published in the Journal of the American Medical Association (Vol. 293 No. 9, March 2, 2005) examines the effect of treatment with folate and vitamin B12 to reduce the incidence of hip fractures in patients after having a stroke.

The researchers suggested that because stroke patients have an increased risk of subsequent hip fracture, and since hyperhomocysteinemia is a risk factor for both ischemic stroke and hip fractures in elderly men and women, if treatment with folate and vitamin B12 improves hyperhomocysteinemia, then it might also prove effetive in reducing the risk of hip fractures.

The researchers observed, in this double-blind randomized controlled study of 628 patients, that those treated with 5mg folate and 1500ug of vitamin B12, had their homoscysteine levels decrease by 38%, compared to a 31% rise in the placebo group, which correlated to a relative risk of 0.20 for hip fracture compared to the placebo group, (Absolute risk reduction 7.1%) with no adverse effects.

JAMA Abstract: http://jama.ama-assn.org/cgi/content/abstract/293/9/1082

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