Evidenced-based Products

Study Claim: 800mg/day magnesium and 5g/day creatine chelate for two weeks in 35 subjects participating in high-intensity exercise resulted in significant effects in compartmental water shifts, which may indicate a greater availability of cellular creatine.

Published: Brila LR, et al. Magnesium-creatine supplementation effects on body water. Metabolism 2003;52(9):1136-40.

Abstract: This study evaluated magnesium-creatine supplementation on body water and quadriceps torque. Magnesium oxide plus creatine (MgO-Cre) and magnesium-creatine chelate (MgC-Cre) at 800mg magnesium and 5g creatine per day were used for two weeks in 35 subjects in a random, blinded study. Body weights increased for both treatment groups. Significant pre-post differences were noted only for MgC-Cre in intracellular water (ICW) and extracellular water (ECW). McC-Cre had significant peak torque increase, while the MgO-Cre and placebo groups did not. Both treatment groups had increased power. MgC-Cre affects cellular fluid compartments, which may infer more muscular creatine due to its osmotic effect, and with increased cellular hydration, perhaps increased protein synthesis.

Potential Applications: This powder can be used in sports nutrition bars, powder drinks, capsules and tablets to increase energy, power and improve results from energy and speed-producing exercise.

More info: Albion Advanced Nutrition
Tel: +1 586 774 9055
Email: [email protected]
Web: www.albion-an.com

Study claim: Pycnogenol, a standardised extract of French maritime pine bark, has beneficial effects on a wide range of physiological functions.

Published: Rohdewald P. A review of the French maritime pine bark extract (Pycnogenol), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 2002;40(4):158-68.

Abstract: Clinical studies indicate that Pycnogenol is effective in treating chronic venous insufficiency and retinal micro-hemorrhages. It protects against oxidative stress in several cell systems. In asthma patients, symptom scores and circulating leukotrienes are reduced and lung function is improved. Immunomodulation has been observed in animal models and humans with Lupus erythematosus. It antagonises the vasoconstriction caused by epinephrine and norepinephrine by increasing the activity of endothelial nitric oxide synthase. Dilation of small blood vessels has been observed in patients with cardiovascular disease. In smokers, it prevents smoking-induced platelet aggregation. It relieves premenstrual symptoms, including abdominal pain; this action may be associated with the spasmolytic action of some phenolic acids.

Potential applications: Pycnogenol is marketed worldwide as a food supplement or as a herbal drug.

More info: Natural Health Science
Tel: +1 877 369 9934
Web: www.pycnogenol.com

Study claim: Calcium with phosphorous demonstrates greater gains in bone development, soft tissue and bone growth.

Published: Shapiro R, Heaney RP. Co-dependence of calcium and phosphorus for growth and bone development under conditions of varying deficiency. Bone 2003; 32:532-40.

Abstract: This study quantified the effect of variation in calcium intake, with and without supplemental phosphorous, on growth and bone development in growing animals under conditions of varying calcium and phosphorous deficiency. Nine groups of weanling male rats were fed a nutritionally complete diet, except for calcium and phosphorous, for 28 days. This diet provided nine levels of varying calcium and phosphorous repletion, using either calcium carbonate, dicalcium phosphate or tricalcium phosphate. At equivalent levels of calcium supplementation, the two phosphorous-containing salts promoted significantly greater improvement in all the bone variables measuresd, as well as greater body weight gain and diet and calcium utilisation, compared to animals supplemented with calcium only. These results demonstrated both the co-dependence of calcium and phosphorous in bone development and the importance of providing both minerals to support soft tissue and bone growth.

Potential applications: For osteoporosis supplements and foods including orange juice, baked goods, fortified drinks, tablets and powders, calcium phosphate is more effective than calcium carbonate.

More info: Rhodia
Tel: +1 609 860 4464
Email: [email protected]
Web: www.rhodia.com
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