Nobel*** Laureate Dr. Louis Ignarro Played Key Role in Developing Formula -
LOS ANGELES, July 8 -- Herbalife International announced
today the launch of Niteworks(TM), a dietary supplement that contains key
ingredients that assist the cardiovascular system in boosting its own natural
production of nitric oxide. The patent-pending formula was developed in
conjunction with Louis Ignarro, Ph.D., who received a 1998 Nobel Prize in
Physiology/Medicine for his research on nitric oxide and its impact on
Nitric oxide (NO) is a molecule produced naturally in the body's
endothethial cells, which line the inside of the arteries. NO is responsible
for dilation of arteries that increase blood flow thereby enhancing vascular
elasticity and exercise capacity. Studies have also shown that young, healthy
and athletic individuals produce more endothelial NO, compared with older,
sedentary and unhealthy individuals.
"Niteworks(TM) is first in a new series of science-based cardiovascular
wellness products to be developed in conjunction with Dr. Ignarro," said
Michael O. Johnson, chief executive officer at Herbalife. "This, and future
products, will make a major impact in promoting nutrition and wellness into
the 21st century."
While numerous studies have shown the impact of NO in the body, not many
people are familiar with it. In a survey conducted for Herbalife by NFO(1),
67% of respondents indicated they had heard of nitric oxide yet less than 1%
of the respondents could correctly identify that nitric oxide was a blood
circulation aid. Only 5.9% understood that increasing their nitric oxide
levels could improve their cardiovascular health. 24% of the respondents
confused nitric oxide with laughing gas (nitrous oxide).
More than 100,000 miles of blood vessels and arteries run throughout the
body, nourishing every organ and tissue with oxygen and nutrients, while also
helping eliminate waste, hence the importance of NO and a healthy vascular
system. Today's all-too-common lifestyle of poor diets and little exercise,
coupled with aging, are all factors that can contribute to cardiovascular and
other health problems. Obesity is becoming a worldwide health crisis, with two
thirds of the adult population in the U.S. being overweight. Since Dr.
Ignarro was awarded the Nobel Prize, more than 17,000 studies have been
conducted by scientists on the biology of NO. Ignarro, who also directs the
Center for Vascular Biology at UCLA, is committed to improving cardiovascular
health and has spent the past several years translating his research into
usable applications for consumers. Niteworks(TM) was designed to help boost
endothelial production of NO, but is ever more important for individuals with
less than optimal lifestyles.
"Nitric oxide is a very important messenger, or signaling agent in the
body, in terms of providing cellular protection," said Dr. Ignarro, currently
a professor of pharmacology at University of California (UCLA). "Researching
nitric oxide for the past 30 years and making the discovery that it is
important for cardiovascular health is not the same as making this knowledge
available to the public at large. I agree with Herbalife's philosophy of the
importance of cellular nutrition and that corresponds with my desire to
translate this science into a product that everyone can benefit from."
Dr. Ignarro formulated Niteworks(TM) based on his special understanding of
the pharmacology of NO and cardiovascular health. Niteworks(TM) contains: an
amino acid complex for NO production, an antioxidant package for NO
protection, and other heart-healthy ingredients. The amino acid complex
includes: L-arginine, which is transported into endothelial cells to produce
NO, and L-citrulline, which is transported by a different mechanism and then
is recycled into L-arginine, creating more NO. This different mechanism is
important because when the L-arginine transporter sees too much L-arginine, it
stops absorbing, so less L-arginine in the systems means less NO production.
The use of L-citrulline in Niteworks(TM) makes it unique compared to other
products in the market. The antioxidant package includes both vitamin E and
vitamin C which protect NO against free radical destruction and which have
been experimentally demonstrated to work synergistically with L-arginine to
produce enhanced levels of NO, and alpha lipoic acid which helps recycle these
vitamins. Heart-healthy ingredients include folic acid and the more
bioavailable cacium folinate to reduce homocysteine. Niteworks(TM) also
contains lemon balm, an herb that assists in relaxation.
Exercise increases the production of NO. But even with a regular exercise
regimen, the body may not produce sufficient quantities of NO to maintain
normal levels in unhealthy cells. Natural sources of L-arginine can include
nuts, fruits, dairy and meats, while natural sources of L-citrulline can
include melon rinds and cucumbers. A low-fat diet also helps increase the
body's production of NO. However, it can be difficult to get as much of the
amino acids from natural sources as is contained in Niteworks(TM).
Due to the high levels of antioxidants in Niteworks(TM), Herbalife is one
of the first companies to offer a product bearing FDA's new qualified
antioxidant health claim that 'consumption of antioxidant vitamins may reduce
the risk of certain kinds of cancer.'**
Niteworks(TM) is taken at night, when the body's own production of NO is
likely to be at its lowest. It is a lemon-flavored powder that is mixed with
water or juice before bedtime. Cost: $89.95 for a 30-day supply. All
Herbalife products are available by calling 1-888-4HERBAL or contacting a
local Herbalife distributor.
About Louis Ignarro, Ph.D.
In addition to being a Nobel*** Laureate, Dr. Ignarro received the Basic
Research Prize of the American Heart Association for his outstanding
contributions to the advancement of cardiovascular science in 1998. Dr.
Valentin Fuster, then president of the American Heart Association, called the
nitric oxide discovery "one of the most important in the history of
cardiovascular medicine." Among his many distinctions, he was inducted into
the National Academy of Sciences in 1999 and into the Academy of Arts and
Sciences the following year. Dr. Ignarro is a new member of Herbalife's
Scientific Advisory Board.
About Herbalife International
Herbalife is a leading company in science-based weight management and meal
replacements. The Company offers a wide range of weight management products,
nutritional supplements and personal care products intended to support weight
loss and a healthy lifestyle. The Company's products are marketed through a
network marketing system comprising approximately one million independent
distributors who conduct business in 58 countries in the Asia/Pacific Rim,
Europe and the Americas. In 2002, the Company had gross revenues of
$1.8 billion. For more information, visit http://www.herbalife.com .
1. Herbalife commissioned the survey, which was conducted by NFO Plog
Research, Inc., a subsidiary of NFO WorldGroup. The survey was
conducted June 6 - 8, 2003 by telephone among 612 respondents who were
drawn from a national sample of adults aged 18 and older. The survey
has a margin of error of +/- 4 percentage points.
* These statements have not been evaluated by the Food and Drug
Administration. This product is not intended to diagnose, treat,
cure or prevent any disease.
** Some scientific evidence suggests that consumption of antioxidant
vitamins may reduce the risk of certain forms of cancer. However, FDA
has determined that this evidence is limited and not conclusive.
*** The Nobel Prize is a registered trademark of The Nobel Foundation.