Aker BioMarine announces a publication of a new preclinical study on krill oil and its effect on the endocannabinoid system that is dysregulated in obesity in the journal Nutrition & Metabolism. Researchers from Australia and Italy performed a study where they investigated the effect of krill oil in mice fed a high fat diet with or without 3 different doses of krill oil. This animal model is widely used to mimic an obese state in humans.
The study results showed that feeding a high fat diet to mice compared to animals given a low fat diet led to an elevation of endocannabinoids (EC), lipid messengers that can activate specific receptors, thereby influencing not only enzyme activities, but also appetite, energy balance, mood, memory, and pain perception. In doing so, the EC system contributes to visceral fat accumulation. Superba krill oil was able to counteract the high fat diet-induced changes in EC levels after 8 weeks of treatment. In addition to reducing EC levels in several different tissues, administration of krill oil also exerted lowering effects on triglyceride, cholesterol and a marker of inflammation.
According to study author Kjetil Berge, PhD, "These findings support previous animal and clinical studies performed with Superba krill oil that is characterized by a high content of omega-3 phospholipids. Hence krill oil has a high potential to alleviate metabolic dysfunctions associated with obesity and other metabolic disorders. "
As a consequence of the results seen in preclincal models of obesity, Aker BioMarine has initiated a clinical study to fully unravel the potential of krill in obese subjects. "The preliminary results from this study in obese human subjects are promising and we expect to publish them soon," says Matts Johansen, EVP, Sales and Marketing, Aker BioMarine.
Interestingly, a recent review article by Kim, J. et al. also suggested that the EC system may be a target for dietary intervention with omega-3 fatty acids to reverse a dysregulated state and positively influence insulin sensitivity and body fat deposition. In particular, krill oil was highlighted as one of the intervention candidates to alleviate diseases associated with EC over activity.
Aker BioMarine is the only krill ingredient marketer that is primary in its supply. Aker's proprietary Eco-Harvesting(TM) technology and on-board processing result in the unique composition of Superba(TM) Krill Oil and provide full traceability from sea to shelf. The Marine Stewardship Council (MSC) has granted MSC Certification to Aker's fisheries, an exclusive distinction that no other krill fishery has earned. As part of an established commitment to substantiating krill's health benefits, Aker continues to sponsor in vitro, in vivo, and human clinical trials with phospholipid EPA & DHA from krill oil, consistently demonstrating a higher uptake of phospholipid omega-3 fatty acids, improved blood lipid profiles, and increased uptake of DHA in brain tissue compared to other omega-3 fatty acid sources.
Piscitelli, F. et al.,"Effect of dietary krill oil supplementation on the endocannabinoidome of metabolically relevant tissues from high fat-fed mice." Nutrition & Metabolism, 8:51, is available online at: http://www.nutritionandmetabolism.com/content/8/1/51/abstract
Kim, J. et al., "Endocannabinoid signaling and energy metabolism: A target for dietary intervention." Nutrition, 2011, 27(6); 624-632, is available online at: http://www.nutritionjrnl.com/article/S0899-9007(10)00391-6/abstract
About SuperbaTM KrillOil
SuperbaTM Krill Oil is a pure, natural source of the health-promoting EPA & DHA omega-3 essential fatty acids and the naturally occurring antioxidant astaxanthin. The uniqueness of SuperbaTM Krill Oil is that the omega-3 fatty acids are provided in phospholipid form. In vitro, in vivo and human clinical research has demonstrated the safety and efficacy of SuperbaTM Krill Oil.
About Aker BioMarine
Aker BioMarine is an integrated biotechnology company dedicated to the sustainable harvesting of krill and development of krill-derived biotech products. The company supplies biomarine ingredients through an optimized value chain from raw materials to customers. Aker BioMarine's SuperbaTM Krill products are provided with 100-percent traceability from the Antarctic sea to the end user. Only Aker's krill fishery has been awarded Marine Stewardship Council (MSC) Certification.