Longevinex® (Licaps®, Capsugel®) Preserves Trans Resveratrol in Red Wine

San Dimas, CA -- March 15, 2006 -- Independent laboratory studies of Longevinex® resveratrol/red wine extract dietary supplements, encapsulated in an airtight gelatin capsule (Licaps®, Capsugel®), confirms that this method of encapsulation inhibits undesirable degradation and molecular conversion of resveratrol over an extended period of time. Longevinex® (Licaps®) capsules retained total resveratrols 40% better, and minimized undesirable molecular conversion of trans resveratrol to cis resveratrol more than 6.5 times better, than conventional tablets or capsules.

Resveratrol, a molecule found in red wine and other botanical sources, is widely known to be the chief molecule that produces the “French Paradox,” the fact that the French live longer and healthier despite a high-calorie, high-fat diet.* Researchers are aware that resveratrol, can degrade, and that trans resveratrol, the primary active form, can convert to the less active cis resveratrol, upon exposure to light, heat and oxygen during encapsulation and storage.

Longevinex®, a proprietary combination of red wine and other antioxidant stabilizing molecules obtained from botanical sources, mimics research-grade production standards, and is never exposed to light, oxygen or heat during production or storage. Studies conducted by an independent laboratory shows Longevinex® (Licaps®) retains 96% (87-100%) of total resveratrols over a 2-year period.

For comparison, 5 brands of conventionally-made resveratrol pills (2-piece gelatin capsules or tablets) averaged a 44% (12-90%) loss of total labeled resveratrols over time.

Three different production lots of Longevinex capsules maintained high amounts of trans resveratrols (93-98% of labeled dosage) over a 2-year shelf life period (+- 4-5% for variance in raw materials). On average, there was only 4% undesirable conversion to cis resveratrol in Longevinex capsules versus 26% in 5 competing brands of resveratrol supplements. Trans resveratrol, considered the more biologically active molecule, is the form of resveratrol known to activate the Sirtuin 1 DNA-repair gene.

Resveratrol has received recent attention in news and scientific reports for extending the life of fish [Current Biology, Feb. 7, 2006 and as a biological mimic of calorie restriction.* [Scientific American, March 2006]

Another recent report suggests resveratrol fulfills the definition of a preconditioning compound that promotes a healthy heart.* [Molecular Interventions, Feb. 2006]

Biologists have also recently documented that trans resveratrol activates a DNA repair gene (Sirtuin 1) that is associated with the prolonged lifespan of yeast cells, fruit flies, roundworms, and most recently, fish.* [Nature, August 5, 2004]

Longevinex introduced its synergistic combination red wine extract dietary supplement (trans resveratrol, quercetin, rice bran, lecithin) in 2004 (patent applied for), which is designed to synergistically preserve and prolong the biological action of trans resveratrol in a dietary supplement. Unlike wine, Longevinex contains no alcohol, sugar or sulfite preservatives. For more information, visit www.longevinex.com

*This statement has not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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