Natto K2 Branded Vitamin K Ingredient for Bone Health Now Available Exclusively From Natural Inc.

VERNON HILLS, IL (February 18, 2003) – Natural Inc., a leading provider of clinically substantiated branded ingredients for the dietary supplement market, is pleased to announce the launch of Natto K2™, a new ingredient high in Vitamin K2, that is a pure natto extract. Natto is a traditional Japanese product consisting of fermented soya beans. Natto, with its high Vitamin K2 content, has an extensive amount of research supporting its benefits for promoting healthy bone density and staving off osteoporosis, in addition to warding off a number of other age-related diseases. This unique branded ingredient is sure to revolutionize the market for bone health supplements, and is now available to U.S. dietary supplement manufacturing and marketing partners as an encapsulated product.

Generations of Japanese have known of the curative effects of natto and have conducted scientific studies that document its positive effects on osteoporosis for more than a hundred years. A Japanese company has finally succeeded in extracting the active ingredients of natto and is now manufacturing a pure natto extract. Only Natural ASA, Natural Inc.’s parent company based in Oslo, Norway, has the exclusive right to market this extract in North America, and will use the company’s own trademark Natto K2™.

New research indicates that Vitamin K, and in particular the Vitamin K2 found in Natto K2, can be crucial in preventing a number of age-related maladies. Epidemiological studies [1,2,3,4,5] show a correlation between high natto consumption and a lower incidence of osteoporosis. Specifically, a scientific study from Europe [6] has recently confirmed a previous study from Japan [7] demonstrating that people receiving Vitamin K, in addition to calcium and Vitamin D supplements, had much healthier bone structure than those who did not include Vitamin K. While calcium is an important factor in preventing osteoporosis, it is not always sufficient on its own. A number of Western countries have a high intake of calcium from dairy sources, among others, yet they nonetheless experience many cases of osteoporosis. Vitamin K2’s unique mechanism of action not only inhibits cells that break down bone tissue, but it has also been proven to stimulate cells that form bone tissue.

Natto K2™ is available exclusively from Natural Inc. and the Vitamin K2 content can be delivered to specification. For more information, please contact us at 847.362.2226.

Natural Inc. is a division of Natural ASA, a publicly-traded Norwegian company and a leader in the development of scientifically based ingredients for the worldwide nutrition industry. Natural Inc. exclusively markets and promotes specialized branded ingredients, including Natto K2™, to the dietary supplement industry.


1. Feskanich D, Weber P, Willett WC, Rockett H, Booth SL, Colditz GA(1999) Vitamin K intake and hip fractures in women: a prospective study. Am.J.Clin.Nutr. 69:74-79

2. Jie KG, Bots ML, Vermeer C, Witteman JC, Grobbee DE (1996) Vitamin K status and bone mass in women with and without aortic atherosclerosis: a population based study. Calcif. Tissue Int. 59:352-356

3. Luukinen H, Kakonen SM, Pettersson K, Koski K, Laippala P, Lovgren T, Kivela SL, Vaananen HK (2000) Strong prediction of fractures among older adults by the ratio of carboxylated to total serum osteocalcin. J.Bone Miner.Res. 15:2473-2478

4. Tsukamoto Y, Ichise H, Kakuda H, Yamaguchi M (2000) Intake of fermented soybean (natto) increases circulating vitamin K2 (menaquinone-7) and gamma-carboxylated osteocalcin concentration in normal individuals. J.Bone Miner.Metab 18:216-222

5. Kaneki M, Hedges SJ, Hosoi T, Fujiwara S, Lyons A, Crean SJ, Ishida N, Nakagawa M, Takechi M, Sano Y, Mizuno Y, Hoshino S, Miyao M, Inoue S, Horiki K, Shiraki M, Ouchi Y, Orimo H (2001) Japanese fermented soybean food as the major determinant of the large geographic difference in circulating levels of vitamin K2: Possible implications for hip-fracture risk. Nutrition 17: 315-321

6. Braam LAJLM, Knapen MHJ, Geusens P, Brouns F, Hamulyák K, Gerichhausen MJW, Vermeer C (2002) Vitamin K1 supplementation retards bone loss in postmenopausal women between 50 and 60 years of age. Thesis publication “Effects of high vitamin K intake on bone and vascular health, ISBN 90-5681-145-2, accepted for publication Calcif.Tissue Int.

7. Takahashi M, Naitou K, Ohishi T, Kushida K, Miura M (2001) Effects of vitamin K and/or D on undercarboxylated and intact osteocalcin in osteoporotic patients with vertebral or hip fractures. Clin.Endocrinol. (Oxf) 54:219-224

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