At a presentation at the American Society for Microbiology meeting in Atlanta today, researchers were told of a safe, natural and effective treatment for MRSA infections that are multi-drug resistant.
Researchers belive the mechanism of action of allicin might be due to inhibition of certain thiol-containing enzymes in the microorganisms by the rapid reaction of thiosulfinates with thiol groups. This was assumed to be the main mechanism involved in the antibiotic effect of allicin, although recent studies have suggested that the mechanism of action of Allicin may be its ability to react with a model thiol compound (L-cysteine) to form the S-thiolation product S-allylmercaptocysteine. (The identification of the thiolation product was proven by nuclear magnetic resonance as well as by mass spectroscopy.)
The main antimicrobial effect of allicin is due to its interaction with important thiol-containing enzymes. In the amoeba parasite, allicin was found to strongly inhibit the cysteine proteinases, alcohol dehydrogenases as well as the thioredoxin reductases (Ankri et al., unpublished results) which are critical for maintaining the correct redox state within the parasite. Inhibition of these enzymes was observed at rather low concentrations (<10 mg/mL).
Allicin also irreversibly inhibited the well known thiol-protease papain, the NADP+ dependent alcohol dehydrogenase from Thermoanaerobium brockii and the NAD+ dependent alcohol dehydrogenase from horse liver.
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Peter Josling, Director
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James R. Walton , President
Allimax Nutraceuticals US