Results of Largest Clinical Trial Examining Effects of Diachrome on Cholesterol and Triglycerides Presented at American Heart Association's 6th Annual Conference on Arteriosclerosis, Thrombosis and Vascular Biology
WASHINGTON, May 2, 2005 -- Nutrition 21, Inc. (NXXI) reported today results from a new randomized double-blind, placebo-controlled multi-center study that showed daily supplementation with Diachrome(R), a combination of Chromax(R) chromium picolinate and biotin, significantly reduced cardiovascular disease risk factors in people with type 2 diabetes. The study, which evaluated 368 subjects over 12-weeks, was presented today at the American Heart Association's 6th Annual Conference on Arteriosclerosis, Thrombosis and Vascular Biology in Washington, D.C. Heart disease strikes people with diabetes twice as often as people without diabetes. More than 65 percent of deaths in diabetes patients are attributed to heart and vascular disease.
The study results presented included an analysis of diabetic subjects (n=234) who had high non-HDL cholesterol levels (a measurement of "bad" cholesterol). Of these subjects, forty percent were already receiving statin therapy or other cholesterol lowering drugs. When Diachrome was added daily to current treatment regimens, non-HDL cholesterol was significantly lowered (-14 mg/dL) compared to the placebo group. In addition, after 12 weeks of supplementation, subjects taking Diachrome had significantly lower triglyceride levels compared to those in the placebo group (225 mg/dL vs. 278 mg/dL).
"These results are impressive since glucose lowering medications do not commonly reduce bad cholesterol levels, and frequently raise them as a side effect. The ability for Diachrome to reduce non-HDL cholesterol levels, a known cardiovascular risk factor, is very important in this population because heart disease is the leading cause of death in patients who suffer from diabetes," said lead researcher Cesar Albarracin, M.D., Medical Director of Alpha Therapy in Corpus Christi, TX. "The findings from this study suggest that Diachrome can serve as a safe and effective adjunct therapy to diet and prescription medications in lowering both blood glucose and cholesterol levels."
Nutrition 21, Inc. conducted the study in collaboration with XLHealth, a nationally recognized disease management firm handling chronically ill patients for the Centers for Medicare and Medicaid Services (CMS). "This study underscores the promise of Diachrome in helping to prevent cardiovascular disease risk factors in people with type 2 diabetes. We are scheduled to present these data as well as other outcomes related to Diachrome's blood glucose lowering effects with stakeholders in the diabetes community in the months ahead," said Gail Montgomery, president and CEO of Nutrition 21, "As we share these results, we anticipate that physicians and their patients will be eager to incorporate Diachrome into clinical practice."
Complimentary positive health outcomes from the study using Diachrome supplementation will be presented at the upcoming American Diabetes Association Annual Scientific Sessions in June 2005. Diachrome is a nutritional supplement specifically formulated for people with diabetes. It contains 600 mcg of chromium as Chromax chromium picolinate and 2 mg of biotin. These two compounds are both Generally Recognized as Safe (GRAS) for use as ingredients in food and supplements. It is available for purchase by calling 1-866-DIACHROME or at http://www.diachrome.com.
About Nutrition 21
Nutrition 21 is a nutritional bioscience company and the maker of chromium-based supplements with health benefits substantiated by clinical research. The company markets Chromax(R) chromium picolinate, which is the most-studied form of the essential mineral chromium. Nutrition 21 also developed Diachrome, which is available through diabetes educators or at http://www.diachrome.com. Nutrition 21 holds 36 patents for nutrition products and uses, 27 of which are for chromium compounds and their uses. More information is available at http://www.nutrition21.com.