Part 5: Science, Research and Technology (April 2005)

[4/29/2005] Herb May Alter Cell Response to Cancer Therapeutic Agents
According to an article on Biocompare, researchers at Yale School of Medicine studying Breast Cancer have noted that the herb black cohosh affects the way that cells respond to cancer therapy. Specifically, the researchers noted that the use of the herb increased cell killing by two drugs, decreased the rate of cell killing in another, and had no effect on the rate of cancer cell killing of the fourth drug.
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[4/29/2005] Pilot Study Suggests Flax Lignans May Help With Hair Loss
A small scale pilot study of 10 men between the ages of 20 and 70 and in varying stages of Androgenetic Alopecia (AGA) suggests that supplementation with high lignan flax (standardized 20 percent lignan concentration as secoisolariciresinol diglucoside, or SDG) might have a positive impact on men suffering from AGA, a common form of hair loss. The subjects consumed 250mg of Acatris' LinumLife Extra each day over six months.
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[4/28/2005] Study Examines Oral Vitamin D3 and Calcium for Secondary Prevention of Low-trauma Fractures in Elderly People
A study published in the Lancet examined over 5000 patients aged 70 or older who had suffered a fracture in the previous ten years. The participants were randomly assigned to take a daily supplement of vitamin D3, calcium, both, or a placebo, with the researchers observing no difference in the frequency of subsequent fracture between those taking supplements and the placebo, and in a commentary, the researchers note that study compliance was only moderate, and possibly as low as below 50%.
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[4/28/2005] New study of Human Genome Screen Shows Basis of 5-LOXIN’s Anti-inflammatory Effects
A study published in the April issue of DNA and Cell Biology examines the human genome and inflammatory pathways, comparing 5-LOXIN®, a dietary supplement ingredient, to ibuprofen in an animal model. According to the researchers, the results indicate the ingredient's anti-inflammatory and collagen sparing mechanisms including inhibition of the expression of matrix metalloproteinase and induced expression of VCAM and ICAM, processes involved in inflammation, cell adhesion and protein degradation. 5-LOXIN® is offered by US-based PL Thomas in alliance with India-based Laila Nutraceuticals.
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[4/26/2005] OatVantage Proves Superiority In Building Cholesterol-Lowering Viscosity
US-based Nurture, Inc. in a study presented at the recently concluded Experimental Biology 2005 Conference in San Diego, reported an intestinal viscosity study by researchers at the University of Minnesota, who reported that the company's OatVantage(TM) concentrated oat soluble fiber resulted in substantially higher viscosities than other oat products previously tested, 50% higher than cooked oatmeal, 70% higher than cold-toasted oat cereal and 202% more than cooked oat bran.

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[4/26/2005] Probiotics May Fight Ulcerative Colitis
According to research published in the Medical Post, (April 26, 2005 Volume 41 Issue 16), Canadian and Italian researchers gave 34 patients with ulcerative colitis a cocktail of 8 probiotic species for six weeks, observing that 53% of the patients had achieved remission, with 24% showing significant response. According to the article, the product, VSL#3, contains 4 strains of Lactobacillus, 3 strains of Bifidobacterium and 1 strain of Streptococcus, and is commercially available at a price of $200 per month.
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[4/26/2005] Two Weight Loss Products May Trigger Thyrotoxicosis
According to a review on Medpage today, citing a case report in the April 25 issue of Archives of Internal Medicine, researchers in Japan and the US have reported that the herbal supplements Dream Shape and Ever Youth, have rapid effects on thyroid hormone levels. According to the review, the products are of Chinese origin, both products are available in Japan and Dream shape is available in the US. The researchers note that Dream Shape contains hydrangea vine, maltose, chrysanthemum, Chinese matrimony vine, saccharose and seaweed, while Ever Youth contains radish, lotus leaf, chrysanthemum, hawthorn, senna tea, Chinese matrimony wine, and seaweed.
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[4/25/2005] Companies Respond to Suggestions of Link Between Cyanobacteria and Neurological Diseases
According to an article in the Honolulu Advertiser, US-based spirulina product manufacturer Earthrise Nutritionals and microalgae company Cyanotech Corp. have responded to a study alleging a link between cyanobacteria (of which spirulina is made) and a class of neurological diseases which include Alzheimer's and Lou Gehrig's disease. The two companies note that the researchers did not study the type of bacteria that produces spirulina when the discovered a neurotoxic amino acid in several different cyanobacteria. The research was presented in the Proceedings of the National Academy of Sciences (April 2005)
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[4/22/2005] Chinese Agency to Initiate Tests on TCM Side Effects
According to an article on citing CCTV International, China's State Administration of Traditional Chinese Medicine has announced that it is going to examine "potential toxic side effects" of Chinese traditional medicine. According to the article, the team from the State Administration will conduct basic experiments on some 72 herbs in the Chinese Pharmacopoeia that have certain toxicity.
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[4/22/2005] Weight Drops on Low Carbs with More Fat or Protein
According to a Reuters health article on Yahoo, Australian researchers, reporting in the American Journal of Clinical Nutrition, have described a study in which 57 overweight and obese subjects used one of two regimens over three months to lose weight. Participants employed either a low-fat, high protein diet, containing fairly generous portions of lean meats and fish a low-fat dairy products, or a high-fat, moderate protein diet with monounsaturated fats from canola oil and nuts, and contained more-moderate amounts of lean meat and dairy. Both plans kept carbohydrates to about one third of daily calories and equal results were observed from each diet.
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[4/21/2005] NCSRT Filtration Equipment Patented for Dairy Separation
US-based process technology company NCSRT, Inc. has announced that it has received three US patents (6,827,960; 6,852,352; 6,875,459) for the company's SmartFlow(TM) technology for separation and purification of milk, whey and colostrum.
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[4/21/2005] GTC Nutrition Responds to Study Challenging Prebiotic Fiber
US-based GTC Nutrition, a business unit of Corn Products International, Inc. (NYSE: CPO) has responded to a recent rat study reporting an association between increased risk of Salmonella infections and large doses of chicory oligofructose, noting that the company's prebiotic offering (NutraFlora scFOS ) is sugar-sourced rather than chicory-based, with a different chemical structure, and a body of scientific evidence, which according to the company, support its efficacy against Salmonella infections.
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[4/20/2005] Green Tea May Curb Prostate Cancer in Men at Risk
According to a Reuters Health article, research from the University of Parma, presented at the American Association for Cancer Research meeting, indicates that green tea catechins (GTC) may prevent the development of prostate cancer in men with a pre-cancerous condition called high-grade intraepithelial neoplasia. The study involved 62 patients provided with either 600 milligrams of catechins daily or a placebo, and the rate of prostate cancer incidence was 3% but 30% in the placebo group.
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[4/19/2005] Traditional Medicine Derivatives Kill Cancer Cells
According to a Reuters Health article, researchers from the Moffitt Cancer Center and Research Institute, in a study published in the Proceedings of the National Academy of Sciences, report on the mechanism of action of derivatives of the indirubin, a compound found in the traditional Chinese medicine, Danggui Longhui Wan. The Chinese herb is used to treat leukemia, and in the current study, the researchers discovered that the compounds induce breast and prostate cancer cells to shut down and die by inhibiting a signaling pathway, known as Src-Stat3.
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[4/19/2005] Study Examines Vitamin D and Sun Effect for Lung Cancer Survival
According to a Reuters article on Yahoo News, results of a Harvard study indicate that patients with high levels of vitamin D, who had surgery in sunny months, had an increased survival rate for lung cancer, compared to those who had low levels of vitamin D and how had surgery in the winter.
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[4/19/2005] Sabinsa's Selenium SeLECT® Found More Bioavailable Than Other Forms of Selenium
Sabinsa Corporation has announced the results of a recent study conducted by researchers at Vanderbilt University, which involved 120 subjects with an average selenium intake of 10 micrograms per day (well below the recommended 55mg per day) who were provided with selenium supplements in either the form of sodium selenite or selenomethionine (Selenium SeLECT). The researchers found that less than half the amount of selenium as selenomethionine was needed to reach optimal levels compared to selenium as selenite, indicating that it is more bioavailable. This study has been accepted for publication in the American Journal of Clinical Nutrition.
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[4/18/2005] Researchers Find How Compound in Chocolate Stops Cancer Growth
According to an article on, researchers at Lombardi Comprehensive Cancer Center at Georgetown, have discovered that a natural compound found in cocoa, entameric procyanidin (pentamer), appears to deactivate proteins that likely push a cancer cell to continually divide. According to the article, the study is funded by Mars Incorporated.
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[4/18/2005] New Study Shows Fish Oil Supplementation Benefits Arthritic Patients
Nordic Naturals has announced the results of a human trial presented at the American Association of Neurological Surgeons' annual meeting, involving adult patients with non-surgical neck or back pain under physician's care supplementing with two (2) capsules daily of the company's EPA(TM) fish oil supplement. According to the researchers, after supplementing for an average of 75 days, 60% of the respondents reported reduction in overall pain and joint pain, and 59% discontinued taking prescription pain medications or non-steroidal anti-inflammatory drugs.
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[4/15/2005] Vitamin E Loss Through Smoking Increases Health Risks
A controlled study published in the American Journal of Clinical Nutrition determined that blood plasma levels of Vitamin E dropped 13% faster among smokers than among the non-smokers, depleting levels much more quickly. According to the Linus Pauling Institute researchers, the study also showed an interactive relationship between vitamins C and E, showing for how inadequate levels of vitamin C can cause further and faster depletion of vitamin E.
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[4/15/2005] New Studies Show Fatty Acids DHA and ARA Significantly Aid Infant Development
Two new studies which Studies used Enfamil Lipil(R) infant formulas from Mead Johnson Nutritionals have been published. One study, published in the April 2005 issue of the American Journal of Clinical Nutrition, shows benefits to visual acuity in term infants, while the other, published in the April 2005 issue of The Journal of Pediatrics, indicates enhanced growth and higher mental and psychomotor development of preterm infants.
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[4/14/2005] Study Examines Ability of Donepezil or Vitamin E to Prevent or Delay Alzheimer’s
According to a Reuters article on Yahoo News, a study published in the New England Journal of Medicine indicates that while Aricept, a drug used to treat Alzheimer's disease and known generically as donepezil, appears to delay its onset in people with mild cognitive impairment, vitamin E had no effect whatsoever. The study involved 769 people given either donepezilor vitamin E or a placebo for three years.
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[4/14/2005] Survey Examines Herbal Product Use Among Those Taking Arthritis Drugs
According to an article on Medical News Today, a survey reported in the Annals of the Rheumatic Diseases, which involved 238 outpatients in Western England with arthritis, reports that 44% of patients had used an herbal or OTC product in the past six months with one in ten patients, according to the researchers, taking a product that could potentially interact with drugs.
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[4/13/2005] Meta-Analysis Examines Effect of Soy Protein Consumption and Risk of Breast Cancer
According to a release issued by The Solae Company, a meta-analysis published in this month's edition of The International Journal of Cancer Prevention indicates that regular consumption of soy protein-containing foods and beverages may reduce the risk of breast cancer in women by as much as 22 percent. The current study is an evaluation of 12 epidemiological studies of populations around the world.
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[4/13/2005] Vitamin C May Reduce Pregnancy Complication
According to a Reuters Health article on Yahoo News, a study involving 109 women, published in the American Journal of Clinical Nutrition, suggests that vitamin C supplementation can reduce the risk of premature rupture of membranes (PROM) that enclose the fetus and amniotic fluids. The participants in the study were assigned to take either 100 milligrams of vitamin C or placebo, beginning at the 20th week of gestation, and the researchers noted that vitamin C levels increased in the supplementation group, with PROM incidence of 25% observed in the control group and 8% in the supplementation group.
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[4/12/2005] Vitamins E and C are Safe Across a Broad Range of Intakes
According to a review article published in the April issue of the American Journal of Clinical Nutrition (Vol. 81, No. 4, 736-745, April 2005) concludes from clinical trial evidence that vitamin E supplements appear safe for most adults in amounts less than 1600 IU and vitamin C supplements under 2000mg per day are safe for most adults.
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[4/12/2005] Dietary Soy and Fish Oil Work Quickly to Improve Cardiac Function
According to an article on Medpage today, citing a study published in the April issue of Chest, researchers from Emory and elsewhere, in a randomized study, examined the heart rate variability of 58 elderly nursing home residents over an 11 week period. Half of the subjects were provided with a 2 gram fish oil supplement, while the other half were given a 2 gram soy oil supplement containing plant-source omega-3's. According to the article, the researchers concluded that supplementation with fish oil correlated with a significant increase in heart rate variability while supplementation with soy oil correlated with a lesser, but still significant increase. (Reduced heart rate variability is a predictor of mortality and cardiac arrhythmia.)
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[4/12/2005] Researchers Study High Folate Intake and Mental Decline in Elderly
According to a Reuters Health article on Yahoo News, in a study published in the April issue of the Archives of Neurology, researchers report that study participants in the top fifth of folate intake, typically consuming more than 700 micrograms folate a day, had twice the rate of mental decline over six years as those who with the lowest folate intake. The researchers followed 3700 adults aged 65 and older, and according to the researchers, there is uncertainty as to whether the folate was associated with the decline, or whether the folate intake was masking other deficiencies.
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[4/12/2005] Study in Journal of Nutrition Confirms Tonalin® CLA Helps Keep Off Lost Body Fat
According to a study published in the April issue of the Journal of Nutrition, researchers note that overweight subjects who took 3.4 grams of conjugated linoleic acid (CLA) per day lost body fat in the first 12 months of the study, and were able to avoid regaining that fat in the second 12 months. The researchers concluded that up to 9% of the body fat in overweight adults might be lost, observing that lean body mass is maintained. The CLA used in the study was Cognis' Tonalin® CLA.
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[4/11/2005] Probiotics Helpful in Infant Eczema
According to an article in Nursing Times, which cites a randomized study in the Journal Allergy, researchers assessed atopic eczema/dermatitis syndrome (AEDS) symptoms in 230 infants with suspected cow's milk allergy, providing them with either Lactobacillus GG (LGG), LGG plus three other probiotics, or placebo capsules mixed with food twice daily for 4 weeks. According to the researchers, LGG alone, but not with the other probiotics, was associated with a significant reduction in symptoms compared to the placebo.
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[4/8/2005] Dietary Interventions Reduce Muscle Weakness in Unloaded Muscle
According to an article on Medical News Today, US researchers, in a mice study funded by the National Space Biomedical Research Institute and the NIH, have determined that the combination of a protease inhibitor made from soybeans and a mixture of antioxidants did not prevent muscle wasting, but both diets lessened the weakness in unloaded muscle.
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[4/8/2005] NCCAM and ODS Co-Fund Five Botanical Research Centers
The National Center for Complementary and Alternative Medicine (NCCAM) and the Office of Dietary Supplements (ODS) have announced funding for five botanical research centers to investigate safety, mechanisms of action and efficacy of botanicals. The funded centers include: Botanical Center for Age-Related Diseases (Principal Investigator Connie Weaver), Botanical Dietary Supplements for Women's Health (Principal Investigator Norman Farnsworth), Botanicals and Metabolic Syndrome ((Principal Investigator William Cefalu), MSKCC Research Center for Botanical Immunomodulators (co-Principal Investigators Barrie Cassileth and Philip Livingston) and Wake Forest and Harvard Center for Botanical Lipids (Principal Investigator Floyd Chilton)
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[4/8/2005] Nutrition 21 Partners with Mandan, Hidatsa and Arikara Nation to Combat Epidemic of Type 2 Diabetes Among Tribal Members
US-based Nutrition 21, Inc. (Nasdaq: NXXI) and the Mandan, Hidatsa and Arikara Nation have announced a collaboration to conduct the first Diachrome® Physician Supervised Health Outcomes Initiative among Native Americans living with type 2 diabetes. According to the company, The program will evaluate the health benefits and costs savings that can be achieved through the use of Diachrome®.
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[4/8/2005] Study Suggests Onion May Slow Bone Loss
According to a Reuters Health article on Yahoo News, from the University of Bern in Switzerland have found that rats with onion added to their diets became significantly less likely to lose bone minerals, and further determined that one ingredient, gamma glutamyl peptide, appeared to be most effective at inhibiting the bone resorption. The study is published in the Journal of Agricultural and Food Chemistry, May 4, 2005.
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[4/8/2005] Vitamin D Fortified Bread Beats Bone-Building Drugs
According to the results of a vitamin D study supported by the Nutritional Resource Foundation and funded by US-based Natural Ovens, elderly patients who ate vitamin D-fortified bread for a period of one year showed better bone mineral density maintenance than that produced by taking bone-building drugs. The results were presented at the FASEB conference in San Diego.
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[4/7/2005] Study Examines Iron Levels and Cancer Risk
According to a Reuters Health Article on Yahoo News, researchers at the Medical University of South Carolina, in a study published in the Annals of Family Medicine, examining a representative sample of U.S. adults, have reported that a combination of high iron stores in the body and high dietary iron intake could raise cancer risk. Previous research had indicated that high iron stores, measured as 'transferrin saturation' at 60 percent or higher might present a cancer risk; the current study suggests that transferrin saturation at 41 percent or higher (that found in about 10 percent of Americans), combined with high iron intake, elevates risk.
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[4/7/2005] Nutritional Supplement Reduces Need For Traditional Ulcerative Colitis Treatment
According to an article on Doctor's Guide, citing a study published in the journal Clinical Gastroenterology and Hepatology, a randomized clinical trial of patients 18 years and older with mild to moderate ulcerative colitis suggests that adding an oral nutritional supplement containing fish oil, antioxidants and soluble fiber diminishes inflammation, has a positive effect on nutrition, and may reduce the need for corticosteroids and other drugs products, in turn reducing drug induced side effects. The research was conducted a The Cleveland Clinic with patients receiving either a placebo drink or the Ulcerative Colitis Nutritional Supplement manufactured by Ross Products and Abbott Laboratories.
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[4/7/2005] Rat Study Suggests Garlic Ingredient Protects Against Pulmonary Hypertension
According to an article on Biocompare, research on rats, conducted at the University of Alabama at Birmingham and presented at the Experimental Biology 2005 meeting in San Diego, suggests that small daily doses of allicin, a compound in garlic, was effective preventing a severe form of pulmonary hypertension.
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[4/6/2005] Study Examines Effect of Alpha-tocopherol Supplementation and Second Primary Tumors
According to an article on Medical News Today, a multi-center, double blind, placebo controlled trial, published in the April 6 issue of the Journal of the National Cancer Institute, examined 540 patients with head or neck cancer who had been treated with radiation therapy and who had received supplementation with alpha-tocopherol and beta-carotene or placebo during and after the radiation therapy. (beta-carotene supplementation was discontinued one year into the three year supplementation period) According to the researchers, patients receiving the supplements had a higher rate of developing a second primary cancer during the supplementation period, compared to placebo, but a lower risk of a second primary cancer after the supplementation ended.
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[4/6/2005] Study Examines Effect of Zinc inTeens
According to a HealthDay article on Yahoo News, U.S. Department of Agriculture research, presented at the Experimental Biology 2005 meeting in San Diego, suggests that adding the mineral zinc to the diets of middle schoolers led to an improvement in memory and attention span. According to the article, the 209 seventh graders were given juice with no zinc, 10 milligrams or 20 milligrams five days a week for ten to twelve weeks.
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[4/5/2005] Study Shows Special Protein May Checkmate Cholesterol
A six week study published in the April issue of the American Journal of Clinical Nutrition (2005 81 (4) p 792) indicates that ImmunoLin®, an immunoglobulin protein isolate developed by Proliant Health Ingredients, was associated with a 6% drop in total cholesterol after three weeks in men and women with moderately high cholesterol, including a 7% decrease in LDL cholesterol while HDL cholesterol levels remained constant. The study was conducted by the Cooper Institute and involved a 5 gram daily dose of Immunolin.
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[4/5/2005] Study Suggests DHA May Improve Cholesterol Particle Size in At-Risk Children
A study on 20 children with inherited high cholesterol, published in this month's American Journal of Cardiology, funded by the National Institutes of Health and using Martek Biosciences Docosahexaenoic Acid (DHA), suggests that supplementation with DHA significantly increased the amount of the large, buoyant LDL (low-density lipoprotein) and large HDL (high-density lipoprotein) particles and decreased the amount of small dense LDL particles, which has been associated with increased risk of cardiovascular events.
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[4/4/2005] Vitamin Use and Risk of Infection in Elderly Studied
According to an Reuters Health article on Yahoo, research reported in the online issue of the British Medical Journal examined selected data from eight studies to determine the effects of multivitamin use on infection outcomes in 1250 elderly subjects. The UK-based researchers concluded that in three studies routine multivitamin use cut the annual number of days spent with infection by 18, while in an analysis of other studies, use had virtually no effect on the risk or rate of infection.
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[4/4/2005] New Study Shows Chromax® Chromium Picolinate is Better Absorbed Than Other Forms of Nutritional Chromium
According to a release issued by Nutrition 21, Inc. (NASDAQ: NXXI), a study conducted by Ohio State University Department of Nutrition, and presented at the Federation of American Societies for Experimental Biology (FASEB) annual meeting in San Diego compared absorption of four different types of nutritional chromium at a dose of 200 mcg, in the form of: Chromax chromium picolinate, chromium chloride, chromium niacin amino acid chelate and chromium nicotinate. The researchers observed in the crossover study of twelve women that those who consumed chromium picolinate absorbed a significantly higher amount of chromium, based on 24-hour urine content analysis.
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[4/4/2005] Enzymotec To Present the Results from CardiaBeat Clinical Study at the FASEB Conference
Israel-based Enzymotec, has noted that Dr. Isabelle Demonty will present new findings from a year and a half long study, conducted by Prof. Peter Jones and his team at the McGill University, Canada on the company's CardiaBeat(TM) product. The session entitled "Dietary Bioactive Compounds: Modulation of Physiological Processes II" will take place on April 4th at 9:15 AM, at the Convention Center.
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[4/4/2005] New Study Suggests Being 'Choosy' About Carbohydrates and Other Foods May Be More Important Than Counting Calories
Researchers at Radiant Research in Chicago have found that overweight and obese adults who followed the principles of The South Beach Diet(TM) (Rodale, 2003) lost more weight and body fat compared to dieters who adopted a low-fat, portion-controlled plan. The results of the study, funded by Kraft Foods, are to be presented at the Experimental Biology scientific conference in San Diego.
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[4/1/2005] Pollinosan Shown Effective in New Clinical Trial
Bioforce USA has announced publication of a study involving A. Vogel Pollinosan homeopathic allergy relief remedy. The study, published in GanzheitsMedizin, (16; 434-428, 2004) suggests that use of the product for 14 days by participants experiencing moderate to severe symptoms of hay fever, led to a reduction in evening hay fever symptoms and improvement in quality of life.
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[4/1/2005] Supplement to be Investigated as Possible Answer for Malnutrition
According to an article on South Africa's IOL, that country's University of KwaZulu-Natal is beginning clinical trials on a high protein supplement product called Sibusiso Ready Food, composed of groundnuts and soya powder, as a potential answer for the area's malnutrition. According to the article, the product would be primarily used for weight gain.
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