Part 5: Science, Research and Technology (Jan. 2005)

Companies in the News: Nature's Way Products, Council for Responsible Nutrition, Source One(TM) Global Partners, Nutrition 21, XL Health Corporation, Pronova Biocare, Sunko Ink, Neptune Technologies & Bioressources, Jarrow Formulas, Destiny Health & Wellness, Nordic Naturals, Enzymotec, American Herbal Products Association, Wyeth Consumer, BASF Corporation, DSM Nutritional Products, Oxford Natural Products.


1/31/2005 - Project Tries to Boost Fatty Acid in Milk
According to an Associated Press article, researchers at CornellUniversity are attempting to alter the diet fed to dairy cows, to increase the amount of conjugated linoleic acid (CLA) in the milk they produce. According to the article, CLA is a by-product of metabolism in the cow's first stomach, where bacteria convert foods containing linoleic acid (corn and soybeans) into CLA.

Link: http://www.sacbee.com/24hour/business/story/2069397p-10128816c.html

1/28/2005 - Research Shows Product Shortens Duration of Common Cold
US-based Nature's Way Products, Inc., has announced the results of a randomized, double-blind, placebo-controlled, multi-center study presented at the First International Conference on Natural Products and Molecular Therapy, which indicate that UMCKA(R) COLDCARE(TM), a proprietary medicine made from Pelargonium sidoides roots, significantly shortens duration and reduces severity of the common cold.

Link: http://www.npicenter.com/anm/templates/newsARes.aspx?articleid=11563&zoneid=28
Link2: http://www.naturesway.com/

1/28/2005 - Council for Responsible Nutrition Sponsors Workshop "Vitamin E: Impact on Health and Disease."
US-based trade association, the Council for Responsible Nutrition (CRN) sponsored a health and science writer’s workshop at the New York Academy of Sciences yesterday. The speakers list included CRN's Annette Dickinson, Ph.D., Maret Traber, Ph.D., Mary Sano Ph.D., Paul Jacques, ScD, Gerald Lemole M.D., and Mark A. Moyad, M.D., M.P.H.

Link: http://www.crnusa.org/vitaminEimpact

1/28/2005 - Calcium Cuts Women's Colorectal Cancer Risk
Research published in the journal, Cancer Epidemiology Biomarkers and Prevention (Vol. 14, 126-132, January 2005) describes a cohort study of 45,354 women without a history of colorectal cancer, followed for an average of 8.5 years, during which 482 developed colorectal cancer. The researchers examined calcium intake from diet and supplementation noting that those who consumed more than 800mg calcium per day had a 26% reduction in risk compared to those consuming less than 530mg per day, regardless of calcium source. Women who consumed more than 412 milligrams of calcium from dietary sources and also took more than 800 milligrams in supplement form had a 46% lower risk.

Link: http://cebp.aacrjournals.org/cgi/content/abstract/14/1/126
Link2: http://www.reuters.com/newsArticle.jhtml?type=healthNews&storyID=7456445

1/27/2005 - Psychiatric Effects of Ephedra Use: An Analysis of Food and Drug Administration Reports of Adverse Events
An analysis published in the American Journal of Psychiatry (Am J Psychiatry 162:189-191, January 2005) examines 1820 adverse events submitted to the Food and Drug Administration as of September 30, 2001 which noted that they were related to dietary supplements containing ephedra. According to the researchers, Fifty-seven serious psychiatric events were reported, and while noting that two-thirds of all cases involved patients with preexisting psychiatric conditions and /or use of other medications or illicit substances, the researchers concluded that serious psychiatric symptoms could be associated with ephedra use.

Link: http://ajp.psychiatryonline.org/cgi/content/abstract/162/1/189

1/26/2005 - SourceOne Announces Completion of Phase III of Sytrinol(TM) Long-Term Clinical Trial
Source One(TM) Global Partners has announced completion of the third and concluding phase of its clinical trial for the product Sytrinol(TM), a twelve week, double-blind, crossover design, randomized trial of 120 moderately hypercholesterolemic men and women.

Link: http://www.npicenter.com/anm/templates/newsARes.aspx?articleid=11536&zoneid=28

1/25/2005 - Nutrition 21 and XL Health Report Positive Results for Diachrome Clinical Trial in People with Type 2 Diabetes
US-based Nutrition 21, Inc. (NXXI: NASDAQ) and XL Health Corporation have announced the results of a randomized, double-blinded, placebo-controlled clinical trial evaluating the effects of Diachrome(R), a combination of chromium picolinate and biotin, on glycated hemoglobin (HbA1c), fasting plasma glucose, cholesterol and triglyceride profiles in patients with type 2 diabetes. According to the companies, the 453 patient multi-center trial, the largest U.S. study to demonstrate the health benefits of a chromium-based intervention for diabetes, is a stepping stone to move Diachrome into practice as an adjunct therapy for people with diabetes.

Link: http://www.npicenter.com/anm/templates/newsARes.aspx?articleid=11531&zoneid=28
Link2: http://www.nutrition21.com
Link3: http://www.xlhealth.com

1/25/2005 - Recent Study Reinforces the Benefits of Omega-3 for Weight Control
An article published in Lipids 2004 presented the effects on weight reduction in obesity prone animals using different omega-3 concentrates containing EPA or DHA. According to the release issued by Norway-based Pronova Biocare, data demonstrated that the omega-3 concentrate rich in DHA (EPAX 1050 TG) increased oxidation of fat by activating genes that breaks down fat in the mitochondriae and peroxisomes, in addition to reducing the number of fat cells, especially in the abdominal region.

Link: http://www.npicenter.com/anm/templates/newsARes.aspx?articleid=11527&zoneid=28
Link2: http://www.pronovabiocare.com/index.php

1/24/2005 - Herbal Extract Effective in Migraine Prevention
A randomized, placebo-controlled clinical trial of 245 migraine sufferers, with results published in the December 28 issue of the journal Neurology, indicated that a proprietary standardized extract of the root of butterbur, was effective in preventing migraines. According to the researchers, the use of two 75 mg tablets per day of the proprietary butterbur extract Petadolex® (Weber & Weber International, Windmere, FL) reduced the occurrence of migraines by 48% in four months, compared to a 26% reduction for the placebo group.

Link: http://www.npicenter.com/anm/templates/newsARes.aspx?articleid=11509&zoneid=28
Link2: http://www.npicenter.com/anm/templates/newsARes.aspx?articleid=11509&zoneid=28

1/24/2005 - Study on Cancer Preventive Activity of Tomato Carotenoids Published in Molecular Cancer Therapeutics
Researchers at Ben Gurion University and Soroka Medical Center in Beer Sheva, in a study published in the January 2005 issue of Molecular Cancer Therapeutics, noted that carotenoids, act by stimulating the body's antioxidant response element, an established mechanism for activation of the body's defense system against carcinogens and other harmful compounds.

Link: http://www.npicenter.com/anm/templates/newsARes.aspx?articleid=11508&zoneid=28
Link2: http://mct.aacrjournals.org/cgi/content/abstract/4/1/177

1/24/2005 - Taiwanese Plant Shows Efficacy for Hepatitis B
According to an article on www.gov.tw, Taiwan's Industrial Technology Research Institute has discovered a substance in an unnamed Taiwanese plant which shows efficacy against Hepatitis B. According to the article, in vitro experiments suggest the drug is able to prevent the Hepatitis B virus from reproducing and improves ability to fight off inflammation. The technology for the product, BMEC-101, has been transferred to Sunko Ink Co. Ltd., Huang Yi-jung, who will continue research and commercialization.

Link: http://english.www.gov.tw/index.jsp?recid=103066&id=14&viewdate=0

1/24/2005 - Neptune Krill Oil Studied in 'Alternative Medicine Review'
According to a release on PRNewswire, an article published in the December 2004 Alternative Medicine Review describes a clinical trial using Canada-based Neptune Technologies & Bioressources 's Neptune Krill Oil for the management of hyperlipidemia. According to the release, Neptune's NKO(TM) reduced total cholesterol, LDL (bad cholesterol) and triglycerides, and increased HDL (good cholesterol).

Link: http://www.marketwatch.com/tools/quotes/newsarticle.asp?guid=%7b99328137-00A3-4847-8DCF-08AEA15FF877%7d&siteid=mktw&dist=nbk&symb=

1/21/2005 - New Research on Pine Bark and Childhood Asthma
A double-blind, placebo-controlled study published in the November/December issue of Journal of Asthma, examining 60 children aged six to 18 years old, has determined that supplementation with French maritime pine bark extract known as Pycnogenol® enabled the children to significantly reduce or discontinue their use of rescue inhalers more often than those in the placebo group. According to the researchers, the severity of asthma symptoms also decreased.

Link: http://www.npicenter.com/anm/templates/newsARes.aspx?articleid=11498&zoneid=28

1/19/2005 - Folate Intake and the Risk of Incident Hypertension Among US Women
Research published in the Journal of the American Medical Association (JAMA-2005;293:320-329) examined the relationship between folate intake and risk of incident hypertension, concluding that higher folate intake associated with a lower risk of incident hypertension. According to the prospective cohort study, women who consumed at least 1000 micrograms per day of total folate had a 46% lower risk of becoming hypertensive compared with those with an intake less than 200 micrograms per day.

Link: http://jama.ama-assn.org/cgi/content/abstract/293/3/320
Link2: http://story.news.yahoo.com/news?tmpl=story&cid=571&e=19&u=/nm/women_bloodpressure_dc

1/19/2005 - Clinical Study Validates the Benefits of Jarrow Formulas® BioSil(TM)
US-based Jarrow Formulas has announced results of a double-blind, placebo controlled clinical trial on the company's Biosil (TM) product. The results were presented at the International Symposium of the International Society for Bioengineering and the Skin and suggest the product is effective for sun damaged or prematurely aging skin.

Link: http://www.npicenter.com/anm/templates/newsARes.aspx?articleid=11485&zoneid=28
Link2: http://www.Jarrow.com

1/17/2005 - New Research Examines Weight Loss Solution
A recently completed placebo controlled double-blind human clinical trial on 34 subjects, conducted at the University of Toronto, evaluated the effect of ingesting the product abs+, containing conjugated linoleic acid (CLA) and epigallocatechin gallate (EGCG). After a period of 12 weeks, significant loss of body weight in overweight human subjects was observed.

Link: http://www.npicenter.com/anm/templates/newsARes.aspx?articleid=11473&zoneid=28

1/14/2005 - Iron Deficiency Sends Cells Into Tailspin
According to an article on Yahoo News, researchers at DukeUniversity, in a study published in the January 14th issue of Cell, have determined that iron deficiency forces cells to reduce gene activity, which can dramatically change metabolic processes. According to the article, the research involved yeast cells.

Link: http://story.news.yahoo.com/news?tmpl=story&cid=97&e=19&u=/hsn/irondeficiencysendscellsintotailspin
Link2: http://www.cell.com/

1/14/2005 - Interim Results from Clinical Study on Performance of Stress Formula Show Promise
Canada-based Destiny Health & Wellness has announced interim results from a 12 week pilot study on the company's OCTA (TM) product which uses objective and subjective tests to evaluate the effects of stress. These preliminary results include a 5 point reduction in blood pressure, a 15% decrease in urinary Cortisol and a 13% rise in DHEA-S levels.

Link: http://www.npicenter.com/anm/templates/newsATemp.aspx?articleid=11458&zoneid=28
Link2: http://destinywellness.com

1/14/2005 - New Study Shows Benefits for Autism and Asperger’s Syndrome With Essential Fatty Acid Supplementation
Results of a pilot trial, published in the January/February 2005 issue of Autism-Asperger’s Digest, showed the effects of essential fatty acids (EFAs) on language and learning skills in children with autism and Asperger’s syndrome. The 3-month open-label study provided 18 children from 3 to 10 years of age with daily supplemental EFAs in the form of Complete Omega™, a fish oil-based EFA product from Nordic Naturals. The children displayed significant increases in their language and learning skills after supplementation.

Link: http://www.npicenter.com/anm/templates/newsATemp.aspx?articleid=11454&zoneid=28
Link2: http://www.autismdigest.com/
Link3: http://www.nordicnaturals.com

1/14/2005 - New Canadian Human Trial Supports Wide-scope CVD Benefits of CarDiabeat(TM)
Israel-based ingredient company Enzymotec Ltd. has announced the results of a Canadian clinical trial on the company's carDiabeat(TM) product. According to the company, the 18 month clinical study, conducted at the Mary Emily Clinical Research Unit in McGill University, Canada, indicates that carDiabeat(TM) shows significantly better results on the body's total lipid profile in comparison to other supplements in the market, based on monitoring biomarkers in the plasma including total cholesterol, LDL-cholesterol, HDL-cholesterol and total triglycerides levels.

Link: http://www.npicenter.com/anm/templates/newsATemp.aspx?articleid=11457&zoneid=28
Link2: http://www.enzymotec.com

1/13/2005 - Study Concludes DHA Restores Blood Vessel Function in Children With High Cholesterol
A study reported in the December issue of The International Journal of Clinical Pharmacology and Therapeutics, using Docosahexaenoic Acid (DHA) from Martek Biosciences Corporation, has concluded that DHA restores normal blood vessel function in children with inherited high cholesterol.

Link: http://www.npicenter.com/anm/templates/newsATemp.aspx?articleid=11438&zoneid=28

1/13/2005 - Reduced Calorie and Carbohydrate Diet Slows Progression of Alzheimer's Disease
According to an article on Medical News Today, researchers at Mount Sinai School of Medicine have led a study on a mouse model that suggests that reducing caloric intake by 30% slowed amyloid plaque development, a feature of Alzheimer's disease. The study is published in the February issue of the FASEB Journal Express.

Link: http://www.medicalnewstoday.com/medicalnews.php?newsid=18850

1/12/2005 - AHPA to Address Botanical Interactions With Blood-thinning Drugs
US-based trade association, the American Herbal Products Association (AHPA) will participate in a workshop to offer insight and suggestions to guide future research into how dietary supplements interact with some cardiovascular drug therapies. AHPA’s vice president of Scientific and Technical Affairs, Steven Dentali, PhD, will speak on a panel this Friday, during a two-day conference convened by the National Heart, Lung, and Blood Institute in Bethesda, Maryland.

Link: http://www.npicenter.com/anm/templates/newsATemp.aspx?articleid=11431&zoneid=2
Link2: http://www.ahpa.org

1/11/2005 - Phytonutrients in Avocados Can Help Protect against Prostate Cancer According to New UCLA Study
According to research published in this month's Journal of Nutritional Biochemistry, researchers at UCLA have determined that nutrients in avocados can work together to inhibit the growth of prostate cancer cells. The study compared extract of whole avocado fruit versus treatment with pure lutein, and measured inhibition of human prostate cancer cell growth.

Link: http://www.npicenter.com/anm/templates/newsATemp.aspx?articleid=11426&zoneid=28

1/7/2005 - Study Suggests Organic Milk 'Higher in Vitamins'
According to an article on BBC News, research carried out by a team from the Danish Institute of Agricultural Research, indicates that the organic milk they studied had higher levels of vitamin E, omega 3 essential fatty acids and antioxidants. According to the researchers, cows farmed organically produced milk which was 50% higher in Vitamin E than conventionally produced milk, 75% higher in beta carotene and two to three times higher in the antioxidants lutein and zeaxanthine.

Link: http://news.bbc.co.uk/1/hi/health/4153951.stm

1/6/2005 - Research Suggests Herbal Extract Reduces Migraines
According to a study published in Neurology, (December 28, 2004), researchers at Albert Einstein College of Medicine have determined that an extract of the root of the plant butterbur (Petasites hybridus) significantly reduced the frequency of migraine headaches. The researchers compared the efficacy of two different doses of butterbur extract to that of a placebo in about 230 migraine patients who had experienced 2 to 6 attacks per month for the three months prior to the study.

Link: http://story.news.yahoo.com/news?tmpl=story&cid=571&ncid=751&e=2&u=/nm/20050105/hl_nm/migraines_herbal_dc

1/6/2005 - CDC Foundation Announces $3.5 Million Program on the Health Effects of Nutritional Supplementation
The CDC Foundation has announced the launch of a $3.5 million program intended to conduct data analysis and educational activities focused on the potential role of dietary supplementation to address specific nutritional needs. According to the organization, Wyeth Consumer Healthcare is the lead financial supporter of the project, along with BASF Corporation and DSM Nutritional Products, Inc.

Link: http://www.npicenter.com/anm/templates/newsATemp.aspx?articleid=11388&zoneid=2
Link2: http://www.cdc.gov/cdcfound.htm

1/6/2005 - Acetyl-L-Carnitine Improves Pain, Nerve Regeneration, and Vibratory Perception in Patients With Chronic Diabetic Neuropathy
In an analysis in the January issue of diabetes Care, researchers evaluated the results of two studies testing two doses of acetyl-L-carnitine -- 500 milligrams and 1,000 milligrams three times a day in the U.S., Canada, and Europe, determining that acetyl-L-carnitine treatment is effective in relieving symptoms, particularly pain, and improves nerve fiber regeneration and vibration perception in patients with diabetic neuropathy.

Link: http://care.diabetesjournals.org/cgi/content/abstract/28/1/89

1/5/2005 - Study Examines Relationship of Vitamin A Pathway to Breast Tumor Progression
According to a study published in the January 5 issue of the Journal of the National Cancer Institute, defects in vitamin A bioactivity may be a possible contributor to human carcinogenes. Researchers at Mount Sinai School of Medicine in New York, noting that vitamin A is required for activation of the retinoic acid receptor (RAR), demonstrated that the protein CRBP-I in mice plays an essential role in vitamin A storage. They found that down regulation of CRBP-I compromised RAR activity, leading to loss of cell differentiation and tumor progression.

Link: http://www.npicenter.com/anm/templates/newsATemp.aspx?articleid=11384&zoneid=28
Link2: http://jncicancerspectrum.oupjournals.org/cgi/content/abstract/jnci;97/1/21

1/5/2005 - Dietary Zinc Modulation of COX-2 Expression and Lingual and Esophageal Carcinogenesis in Rats
According to research published in the Journal of the National Cancer Institute (Vol. 97, No. 1, 40-50, January 5, 2005), scientists at Thomas Jefferson University, noting that esophageal and tongue cancers have been associated with both dietary zinc deficiency and an over expression of cyclooxygenase (COX-2), have determined that zinc appears to regulate COX-2 expression in vivo in a rat model.

Link: http://jncicancerspectrum.oupjournals.org/cgi/content/abstract/jnci;97/1/40

1/5/2005 - Chamomile Tea Shown to Boost the Immune System
According to an article on News-Medical.Net, a study scheduled to appear in the Jan. 26 issue of the Journal of Agricultural and Food Chemistry, examined German chamomile (Matricaria recutita). According to the article, the study involved fourteen volunteers (seven women and seven men) who each drank five cups of the herbal tea daily for two consecutive weeks. The UK-based researchers found that drinking the tea was associated with a significant increase in urinary levels of hippurate and glycine for a period of up to two weeks after participants stopped drinking the tea. Study funding was provided by UK-based Oxford Natural Products.

Link: http://www.news-medical.net/?id=7126
Link2: http://pubs.acs.org/journals/jafcau/

1/5/2005 - Icrisat Working on Biofortification of Groundnuts
According to an article on the net edition of the Financial Express, the International Crops Research Institute for the Semi-Arid Tropics (Icrisat) has launched research to enhance beta-carotene in groundnut as part of a project to combat malnutrition due to nutrient deficiency.

Link: http://www.financialexpress.com/fe_full_story.php?content_id=78700

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