Patent Awarded for Technical Sourcing's MSV 60

Patent Awarded for Technical Sourcing's MSV 60™

MISSOULA, Mont. (October 31, 2001) – Technical Sourcing International, Inc. (TSI) today announced it has been granted U.S. Patent 6,299,910, for its branded cardiovascular support ingredient, MSV 60™.

The patent, entitled “Methods for identification, purification, and manufacturing of the active constituent in Salvia miltiorrhiza (dansheng) and the application of this product in enhancing cardiovascular functions”, allows TSI to exclusively process the most advanced standardized extract of the Chinese herb, dansheng. The ingredient is branded MSV 60™.

Dansheng, also called danshen, is described as one of the most significant remedies in Traditional Chinese Medicine (TCM) with inclusion in the Chinese Shen-Non Herbal Pharmacopoeia in 2,000 B.C. The herb has historically been associated with the circulatory and cardiovascular systems and consequently has been recommended for conditions surrounding the blood and heart.

The patent claims isolation of eight principal marker compounds and identification of the most biologically effective constituent as Magnesium Salvianolate B. The invention relates to the methods used for water-based extraction and purification of these chemical constituents, identification of the active component, and removal of undesirable compounds. These techniques yield a water-soluble 60% standardized extract. MSV 60™ also contains the eight marker compounds in their natural ratios. All 19 of the company’s claims regarding methods for processing were awarded in the patent.

Validation of cardiovascular function enhancement using MSV 60™ includes research conducted at the Shanghai Institute of Materia Medica (SIMM), a unit of Chinese Academy of Sciences. One study revealed that blood platelet aggregation is lowered significantly (94% inhibition at 900 mcg/ml concentration) when MSV 60™ was administered to animal subjects. Platelet aggregation is known to lead to thrombosis and arteriosclerosis, precursors of cardiovascular disease. Other studies have shown MSV 60™ instrumental in increasing coronary circulation, as well as, heart muscle strength.

Larry Kolb, president of TSI, is pleased the company’s MSV 60™ product is protected for use in cardiovascular products. “Our new patent demonstrates our commitment to developing and producing groundbreaking ingredients and provides our manufacturing partners a significant advantage in bringing sound, efficacious products to market.”

As a dietary supplement, MSV 60™ can be formulated as a single ingredient product or can be incorporated into a multi-ingredient formula with other complimentary nutrients. Readily soluble in water, it lends itself to versatile applications. MSV 60™ shows promise in cardiovascular support products.

About Technical Sourcing International, Inc.

Technical Sourcing International, Inc. (TSI) is a leading researcher, producer, and marketer of nutraceutical ingredients to the dietary supplement, pharmaceutical, and food and beverage industries. Its products include MSV 60ä, OstivoneÒ, Ginkgo 24/6/5ä, Rusperin Cä, PUREFLEXä Chondroitin and Glucosamine, as well as, botanical, marine, and natural product extracts and synthesized compounds. The company is based in Missoula, Mont., and can be reached at (406) 549-9123 or
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