Chatsworth, CA--Renaissance Herbs announces high-potency extracts of Andrographis (Andrographis paniculata) for use in cold & flu formulas. Standardized by HPLC to andrographolides, these extracts are available in grades of 10% and 50%. Andrographis is an extremely bitter-tasting shrub with a substantial history of traditional use in India, China and Thailand.
In the US, publication of placebo-controlled clinical studies on Andrographis for symptoms of the common cold and flu has prompted pharmacists to refer to the herb as ‘Indian Echinacea’. Double-blind, randomized controlled clinical trials of Andrographis in the treatment of upper respiratory tract infections (cold, flu, and pharyngitis) demonstrated that whether used alone or in herbal combination formulas, the herb was significantly more effective than placebo. For example, in Sweden, a study of 50 adults diagnosed with the common cold found that compared to placebo the group taking an extract of Andrographis (standardized to contain andrographolides) had significantly fewer sick leave days and significantly more of them experienced less severity of symptoms. The percentage of patients who found themselves completely recovered by day 5 of the treatment period was also significantly greater in the Andrographis group: 67% vs. 36% (Melchior et al.,
A larger study of Andrographis against the common cold (randomized double-blind, placebo-controlled) in Chile and Sweden in 158 adults also found significant benefits. Noticeable improvements started at day 2 of treatment; both the intensity and prevalence of symptoms were significantly reduced by day 4; and there were no adverse effects. Significant reductions in symptoms compared to placebo were found in soreness of the throat, nasal secretion, cough intensity, cough frequency, expectoration, headache, earache, fatigue, and sleep disturbance (Cáceres et al.,1999).
Similar results are reported in a number of placebo-controlled clinical trials of Andrographis for symptoms of the common cold, whether used alone (Hancke et al., 1995), or in combination with eleuthero (Eleutherococcus senticosus) (Spasov et al., 2004; Gabrielian et al., 2002; Melchior et al., 2000). Clinical studies comparing Andrographis alone to a prescription drug (paracetamol) in the treatment of flu symptoms (Thamlikitkul et al., 1991) and combined with eleuthero versus amantadine (Kulichenko et al., 2003) also reported excellent results.
Renaissance Herbs Andrographis is a pure, solvent-free powder extract made from wildcrafted whole plants.
Renaissance Herbs, Inc. (www.renaissanceherbs.com) is an American company dedicated to the research and development of the finest and most innovative botanical health care products available today. Our 50,000 square foot factory and R & D Center in Bangalore, India provides manufacturers with potent, standardized
botanical extracts backed by Good Manufacturing Practices. The company was founded in 1990 by Alex Moffett and maintains offices in Los Angeles, California, Bangkok, Thailand and Bangalore, India.
Cáceres DD, Hancke JL, Burgos RA, Sandberg F, and Wikman GK (1999). Use of visual analogue scale measurements (VAS) to assess the effectiveness of standardized Andrographis paniculata extract SHA-10 in reducing the symptoms of common cold. A randomized double blind-placebo study. Phytomedicine. 6:217-223.
Gabrielian ES, Shukarian AK, Goukasova GI, Chananian GL, Panossian AG, Wikman G, and Wagner H (2002). A double-blind, placebo-controlled study of Andrographis paniculata fixed combination Kan Jang in the treatment of acute upper respiratory tract infections including sinusitis. Phytomedicine. 9:589-597.
Hancke J, Burgos R, Caceres D, and Wikman G (1995). A double-blind study with a new monodrug kan jang: Decrease of symptoms and improvement in the recovery from common colds. Phytother Res. 9:559-562.
Kulichenko LL, Kireyeva LV, Malyshkina EN, and Wikman G (2003). A randomized, controlled study of Kan Jang versus amantidine in the treatment of influenza in Volgograd. J Herbal Pharmacother. 3:77-93.
Melchior J, Spasov AA, Ostrovskij OV, Bulanov AE, and Wikman G (2000). Doubleblind, placebo-controlled pilot and phase III study of activity of standardized Andrographis paniculata Herba Nees extract fixed combination (kan jang) in the treatment of uncomplicated upper-respiratory tract infection. Phytomedicine. 7:341-350.
Melchior J, Palm S, and Wikman G (1996/97). Controlled clinical study of standardized Andrographis paniculata extract in common cold – a pilot study. Phytomedicine. 3:315-318.
Spasov AA, Ostrovskij OV, Chernikov MV, and Wikman G (2004). Comparative controlled study of Andrographis paniculata fixed combination, Kan Jang® and Echinacea preparation as adjuvant, in the treatment of uncomplicated respiratory disease in children. Phytother Res. 18:47-53.
Thamlikitkul V, Theerapong S, Boonroj P, Ekpalakorn W, Taechaiya S, Orn-Chom- Jan T, Pradipasena S, Timsard S, Dechatiwongse T, Chantrakul C, et al (1991). Efficacy of Andrographis paniculata Nees for phaygngotonsillitis in adults. J Med Assoc Thai. 74:437-442.