Vital stats: Source One Global Partners' coenzyme Q10
Study claim: Bioavailability for CoQsource brand co-Q10 is significantly higher than three other commercially available sources — one oil-based formulation and two solubilisates.
Published: Liu ZX, Artmann C. Relative bioavailability comparison of different coenzyme Q10 formulations with a novel delivery system. Altern Ther Health Med 2009;15(2):42-6.
Abstract: Commercial co-Q10 formulations have notoriously poor intestinal absorption. Researchers investigated the bioavailability of a new co-Q10 formulation based on a new and patented technology, VESIsorb, with three other commercially available co-Q10 products: an oil-based formulation and two solubilisates. This new co-Q10 formulation (commercially branded CoQsource) is a lipid-based formulation that naturally self-assembles on contact with an aqueous phase into an association colloid delivery system (hereafter "colloidal-Q10").
Twenty healthy male and female subjects participated in a double-blind, controlled, parallel-design, single-dose (120mg) bio-availability study. Plasma concentration of co-Q10 was determined at baseline and at various intervals after administration over a 24-hour period. To compare bio-availability, researchers assessed maximum concentration (Cmax) and area under the curve from zero to 10 hours (AUC(0-10h)). The kinetic profiles of all co-Q10 preparations revealed a one-peak plasma concentration-time course. Highest Cmax values were seen after colloidal-Q10 administration.
Colloidal-Q10 not only had the highest plasma concentration levels after one hour, but it continued to increase before reaching Cmax at about four hours. The plasma concentration of colloidal-Q10 remained well above the levels of the three other products throughout the 24-hour period. The relative bioavailability calculated using the AUC(0-10h) values was also the highest for colloidal-Q10; the AUC(0-10h) values were 30.6, 6.1, 4.9, and 10.7μg/mL*h for colloidal-Q10, solubilisate 1, the oil-based formulation and solubilisate 2, respectively. The data suggest that colloidal-Q10 improves the enteral absorption and bio-availability of co-Q10 in humans.
Potential applications: This 100 per cent water-soluble form of co-Q10 is suitable in solid dosage forms, drink mixes, stick packs, food products, beverages and more.
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Vital stats: Triarco's Mytosterone
Study claim: Mytosterone increases total testosterone levels in men by a significant 50 per cent, while reducing DHT and estradiol levels — hormones implicated in male-pattern hair loss and abdominal-fat accumulation.
Published: Angwafor F, Anderson M. An open-label, dose response study to determine the effect of a dietary supplement on dihydrotestosterone, testosterone and estradiol levels in healthy males. J Int Soc Sports Med 2008;5:12.
Abstract: Maintaining endogenous testosterone (T) levels as men age may slow the symptoms of sarcopenia, andropause and decline in physical performance. Drugs inhibiting the enzyme 5-alpha-reductase (5AR) produce increased blood levels of T and decreased levels of dihydrotestosterone (DHT). However, symptoms of gynecomastia have been reported due to the aromatase (AER) enzyme converting excess T to estradiol (ES). The carotenoid astaxanthin (AX) from Haematococcus pluvialis; saw palmetto berry lipid extract (SPLE) from Serenoa repens; and the precise combination of these dietary supplements, Alphastat (Mytosterone), have been reported to have inhibitory effects on both 5AR and AER in vitro. Concomitant regulation of both enzymes in vivo would cause DHT and ES blood levels to decrease and T levels to increase. The purpose of this clinical study was to determine if patented Alphastat (Mytosterone) could produce these effects in a dose dependent manner.
Forty-two healthy males ages 37 to 70 years were divided into two groups and took either 800mg/day or 2,000mg/day Alphastat (Mytosterone) for 14 days. Blood samples were collected on days zero, three, seven and 14, and assayed for T, DHT and ES.
Both dose groups showed significant increases in serum total T and significant decreases in serum DHT within three days from baseline. Significant, dose-dependent decreases in serum ES are reported for the 2,000mg/day dose group, but not the 800mg/day dose group.
Potential applications: Maintaining endogenous testosterone levels is crucial for men's health at every age — from ageing, vitality, energy and mood to bone density and muscle-mass maintenance.
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