VITAL STATS: Streptococcus salivarius K12 probiotic branded as BLIS K12 from Stratum Nutrition
STUDY CLAIM: S. salivarius K12 may inhibit the process of invasion of C. albicans into mucous surfaces or its adhesion to denture acrylic resins by mechanisms not associated with the antimicrobial activity of the bacteriocin.
PUBLISHED: Ishijima SA, et al. Effect of Streptococcus salivarius K12 on the in vitro growth of Candida albicans and its protective effect in an oral candidiasis model. Appl Environ Microbiol. 2012 Apr;78(7):2190-9. Epub 2012 Jan 20.
ABSTRACT: Oral candidiasis is often accompanied by severe inflammation, resulting in a decline in the quality of life of immunosuppressed individuals and elderly people. To develop a new oral therapeutic option for candidiasis, a nonpathogenic commensal oral probiotic microorganism, Streptococcus salivarius K12, was evaluated for its ability to modulate Candida albicans growth in vitro, and its therapeutic activity in an experimental oral candidiasis model was tested.
In vitro inhibition of mycelial growth of C. albicans was determined by plate assay and fluorescence microscopy. Addition of S. salivarius K12 inhibited the adherence of C. albicans to the plastic petri dish in a dose-dependent manner. Interestingly, S. salivarius K12 was not directly fungicidal but appeared to inhibit candida adhesion to the substratum by preferentially binding to hyphae rather than yeast.
To determine the potentially anti-infective attributes of S. salivarius K12 in oral candidiasis, the probiotic was administered to mice with orally induced candidiasis. Oral treatment with S. salivarius K12 significantly protected the mice from severe candidiasis. These findings suggest that S. salivarius K12 may inhibit the process of invasion of C. albicans into mucous surfaces or its adhesion to denture acrylic resins by mechanisms not associated with the antimicrobial activity of the bacteriocin.
POTENTIAL APPLICATIONS: S. salivarius K12 may be useful as a probiotic as a protective tool for oral care, especially with regard to candidiasis.
GliSODin, Isocell, distributed by P.L.Thomas
VITAL STATS: GliSODin—a cantaloupe melon extract rich in vegetal superoxide dismutase (SOD)—is patented and trademarked by Isocell, Paris, France, and exclusively available in North America from PL Thomas.
STUDY CLAIM: GliSODin supplementation demonstrated positive effects on selected inflammatory markers in a 2,000 meter rowing ergometer test.
PUBLISHED: Skarpanska-Stejnborn A, et al. Effects of oral supplementation with plant superoxide dismutase extract on selected redox parameters and an inflammatory marker in a 2,000-m rowing-ergometer test. Int J Sport Nutr Exerc Metab. 2011 Apr;21(2):124-34.
ABSTRACT: The aim of this study was to investigate the effect of plant superoxide dismutase extract (GliSODin) supplementation on the balance of oxidants and antioxidants in the serum and erythrocytes of competitive rowers. The double-blinded study included 19 members of the Polish National Rowing Team who were participating in a training camp. Subjects were randomly assigned to the supplemented group (n = 10), who received two capsules (total 500 mg) of GliSODin® extract once daily for six weeks, or the placebo group (n = 9). At the beginning and end of the study, subjects performed a 2,000-meter maximum effort test on a rowing ergometer. Blood samples were taken before each test, one minute after completing the test, and after a 24-hr rest period. After supplementation, SOD activity was significantly higher (p = .0037) in the supplemented group at all measurement times, and post-exercise C-reactive protein was significantly lower (p = .00001) in athletes receiving GliSODin than those in the placebo group. In conclusion, supplementation with an extract rich in SOD activity promoted antioxidant status and protected against increased inflammation in the serum of professional rowers.
POTENTIAL APPLICATIONS: As a nutritional raw material for use in sports nutrition and immune health products.