A newly published review of CoQ10’s clinical efficacy and bioavailability research has concluded that CoQ10 supplementation has potential therapeutic value for several diseases and health conditions. However, the clinical efficacy in many conditions could be limited by its ability to be absorbed to reach high plasma concentrations required for therapeutic benefit.
This review, published in the January 2011 issue of Journal of Evidence-Based Complimentary and Alternative Medicine is entitled “Coenzyme Q10: Clinical Update and Bioavailability.”
CoQ10 has been implicated as a potential therapy for a large number of health conditions and diseases, especially those that result from reduced mitochondrial function. The review discusses recent clinical research in the areas of neurodegenerative disorders, cardiovascular disease, statin therapy, reproductive health, cancer and periodontal diseases. In addition, the article provides an overview of the fundamentals of CoQ10 absorption and reviews the latest clinical research comparing various enhanced formulation technologies used to improve the bioavailability of CoQ10.
The authors conclude that, at first glance based on clinical studies on healthy subjects, more sophisticated CoQ10 formulations show great potential. Yet, with additional scrutiny of the reported data, it appears that some studies have high intersubject variance, which means a percentage of the population will not experience the improvement in bioavailability. It is recommended that improvements in the standards of reporting the bioavailability of CoQ10 be made to help clinicians and consumers decide whether or not a product is likely to be effective.
“A thorough review of the clinical data pertaining to CoQ10 absorption supports the need for pharmaceutical-level standards for assessing the bioavailability of CoQ10,” said Dan Kagan Ph.D., a Managing Partner at BioActives LLC. “Without these improved standards, especially including inter-subject variation, it becomes difficult for consumers and physicians to feel confident that treatment with CoQ10 will be successful.”
Bank, G., Kagan, D., Madhavi, D. Coenzyme Q10: Clinical Update and Bioavailability. Journal of Evidence-Based Complementary & Alternative Medicine. 2011. 16(2) 129-137.