Study Indicates That GliSODin May Provide Significant Protection Against UV Radiation-induced Skin Changes

June 1, 2005 PL Thomas (PLT) today announced the results of a new study using its exclusive dietary supplement ingredient, GliSODin®, demonstrating significant reduction in susceptibility to sunburn in a model using UV radiation-induced skin changes.

In the double-blind, placebo controlled study, UV skin burn (actinic erythema) was induced on the inner-forearms of healthy subjects before supplementation with GliSODin or placebo, and each week for four weeks during supplementation.

The color of the skin was measured by chromometry, and changes in skin due to inflammation were assessed by videocapillaroscopy, which calculates the congestion of small blood vessels.

According to the researchers, "This study confirms the efficacy of GliSODin in the prevention of the consequences of oxidative stress resulting from exposure to the sun. This efficacy is of particular interest for phototypes II (fair-skinned) that represent a major part of the consultations in dermatology."

The researchers also noted the GliSODin was extremely fast-acting. The GliSODin and placebo supplementation were started just two to three days prior to the first UV irradiation, and despite such a short period there was a noticeable difference between the two groups.

GliSODin supplementation resulted in an increase in the minimum exposure to UV rays necessary to produce skin burn. In particular, phototypes II required eight times greater exposure than that of the placebo.

Further, the redness induced by the skin burn decreased more quickly in the GliSODin group and the increase in the number of capillaries assessed by videocapillaroscopy, demonstrating a reduction in inflammation, was higher in the GliSODin group compared to placebo.

The randomized double-blind study with 50 participants was conducted by researchers at Center Hospital University, Besançon, France, and was presented at the CARD (Annual Congress of Dermatological Research) meeting in Brest on May 28th. The study has been submitted for publication.

Previous published human and laboratory studies have shown GliSODin's effectiveness in protecting cells from oxidative stress by activating the body's production of its own antioxidants, including SOD, catalase and glutathione peroxidase. This "internal antioxidant defense system" is necessary for the elimination of the free radicals produced by oxidative stress.

GliSODin is offered exclusively in North America by PL Thomas in alliance with ISOCELL Nutra, France.

For more information or a copy of the study poster please contact PL Thomas: phone: 973-984-0900, fax: 973-984-5666, e-mail: [email protected] or

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