Clinical Case Study: MultiSpecies Probiotic Supplement Minimizes Symptoms of Irritable Bowel Syndrome

Twenty-five Patient Case Study using Multi-Flora Probiotics for reduction of IBS symptoms demonstrated significant improvement in multiple symptoms.

Eden Prairie, MN 30-April – 2010

Physicians from UND School of Medicine and Mayo Clinic conducted a clinical case study to demonstrate whether using multispecies probiotic could minimize the symptoms of patients with irritable bowel syndrome (IBS). IBS is estimated to affect 20-30% of the population with 30-50% of gastroenterology referrals related to IBS symptoms. In western countries, women are 2-3 times more likely to develop IBS. The causes of IBS are thought to include food intolerance, imbalance of intestinal microflora and colonic malfermentation. For standardized diagnosis for clinical practice, Rome III criteria are used. Earlier studies using probiotics as a therapeutic agent have been promising.

Researchers evaluated 25 patients with IBS as defined by Rome III criteria over a period of 60 days. Patients were treated with a multispecies probiotic product (Multi-Flora Plus) containing Lactobacillus acidophilus DDS®-1 strain, Bifidobacterium longum, Bifidobacterium bifidum and Bifidobacterium lactis with a combined potency of 12 billion CFU/g. Patients’ symptom severity was evaluated on a scale of 1 to 10. Improvement was classified as at least 50% reduction in severity. The most significant improvements occurred after 60 days of treatment with 84% of the patients showing improvement in abdominal pain, 73.9% in bloating, 92% in belching, 88% in flatulence, 90.9% in diarrhea and 86.9% in constipation. No clinically evident side effects were observed.

Symptom

Number of patients showing improvement at the end of month 1

Percentage of patients after 1 month treatment

Number of patients showing improvement at the end of month 2

Percentage of patients after 2 months treatment

Abdominal pain

8/25

32%

21/25

84%

Bloating

12/25

48%

18/25

73.9%

Belching

13/25

52%

23/25

92%

Flatulence

7/25

28%

22/25

88%

Diarrhea*

17/22

77%

20/22

90.9%

Constipation**

19/23

82%

20/23

86.9%

*Diarrhea was noted in 22/25 patients, ** Constipation was noted in 23/25 patients

The GI tract contains both pathogenic and normal commensal bacterial flora. It is possible that an alteration in the balance between commensals and pathogenic bacteria might be responsible for the excessive gas production and lead to a diverse group of symptoms which are similar to IBS. The results of this study are consistent with the idea that probiotic bacteria can help to keep pathogenic bacteria in check. This study has been submitted for publication.

Multi-Flora Probiotics containing the strains, Lactobacillus acidophilus DDS®-1, B. longum, B. bifidum, B. lactis, are manufactured and marketed by UAS Laboratories, Inc. of Eden Prairie, MN. (www.uaslabs.com)

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