Evidence-based products

STUDY CLAIM: Chromax supplementation enhances insulin sensitivity and glucose disappearance and improves lipid profile in male obese hyperinsulinemic rats.

PUBLISHED: Cefalu WT, et al. Oral chromium picolinate improves carbohydrate and lipid metabolism and enhances skeletal muscle Glut-4 translocation in obese, hyperinsulinemic (JCR-LA corpulent) rats. J Nutr 2002 Jun;132(6):1107-14.

ABSTRACT: Human studies suggest that chromium picolinate decreases insulin levels and improves glucose disposal in obese and type 2 diabetic populations. In this study, researchers evaluated Chromax to determine if it may aid in treating insulin resistance syndrome in JCRLA-corpulent rats. Male lean and obese hyperinsulinemic rats were randomly assigned to receive 80mcg/(kg/d) Chromax in water or control conditions. After three months, rats given Chromax had significantly lower fasting insulin levels and significantly improved glucose disappearance compared with obese controls. Obese Chromax-treated rats had lower plasma total cholesterol and higher HDL cholesterol levels than obese controls. Chromax did not alter plasma glucose or cholesterol levels in lean rats. Total skeletal muscle glucose transporter Glut-4 did not differ among groups; however, Chromax significantly enhanced membrane-associated Glut-4 in obese rats after insulin stimulation.

POTENTIAL APPLICATIONS: Chromax is used in dietary supplements to support insulin function.

MORE INFO: Nutrition 21
Tel: +1 800 343 3082

STUDY CLAIM: Over a four-week period, Xenadrine produced significant weight loss and appetite reduction in 18 healthy, overweight females, without any negative cardiovascular effect.

PUBLISHED: Kalman DS, et al. A randomised, double-blind evaluation of the short-term safety and efficacy of a commercial weight-loss product containing ephedra in healthy overweight female volunteers. J Amer Diet Assoc 2002;102(9):S2, A24.

ABSTRACT: In a randomised double-blind, placebo-controlled design, 24 healthy overweight female adults (body mass index 25kg/m2) took either Xenadrine RFA-1 (20mg herbal ephedrine, 5mg synephrine, 200mg caffeine) or placebo daily for four weeks. All subjects consumed a diet equaling 20kcal/kg and exercised four times/week. Outcome measurements included changes in weight, blood pressure, resting and post-dose ingestion heart rate, Visual Analog Scale-appetite ratings and adverse events.

Among the 18 patients who completed the study, Xenadrine RFA-1 produced a significantly greater amount of mean weight loss (2.1kg vs 0.08kg with placebo). Mean appetite reduction was also greater with Xenadrine than with placebo. There were no significant differences in cardiovascular parameters.

MORE INFO: Cytodyne
Tel: +1 888 298 6396

STUDY CLAIM: In a study of organophosphorus exposure from diet, the median total dimethyl metabolite concentration was six times higher for 21 children with conventional diets than for 18 children with organic diets over a three-day period.

PUBLISHED: Curl C, et al. Evaluation of take-home organophosphorus pesticide exposure among agricultural workers and their children. Environ Health Perspect 2002 Dec;110(12):A787-92.

ABSTRACT: Researchers assessed organo-phosphorus (OP) pesticide exposure from diet in pre-school children in Seattle. For three days prior to urine collection, parents kept food diaries in which they distinguished organic and conventional foods based on label information. They also recorded residential pesticide use for each home. Researchers collected urine samples from 18 children with organic diets and 21 children with conventional diets.

The median total dimethyl metabolite concentration was six times higher for children with conventional diets than for children with organic diets. Dose estimates from pesticide metabolite data suggest that consumption of organic fruits, vegetables and juice can reduce children's exposure levels from above to below the US Environmental Protection Agency's current guidelines, thereby reducing exposures to a negligible risk.

POTENTIAL APPLICATIONS: Food formulators can use organic ingredients in order to develop pesticide-free foods.

MORE INFO: University of Washington
Cynthia Curl
Tel: +202 685 1958

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