Pine Tree Bark Reduces Diabetic Microangiopathy

(October 3, 2006) - Hoboken, NJ – Diabetic microangiopathy is responsible for major diabetic health complications, such as leg ulcers, kidney failure and retinopathy. It is imperative diabetics receive the best treatment to manage this condition. A study published in the September edition of Angiology shows that Pycnogenol (pic-noj-en-all), an antioxidant plant extract from the bark of the French Maritime pine tree, significantly reduced diabetic microangiopathy (DM) in patients after supplementing with Pycnogenol.

“Diabetic microangiopathy is not a rare phenomenon and essentially affects every diabetic person. The condition may result in vision loss in diabetic retinopathy, kidney problems and ischemic tissue necrosis causing leg ulcers which may lead to amputation,” said Dr. Gianni Belcaro, a lead researcher of the study. “With DM, the walls of very small blood vessels (capillaries) become so weak, bleeding and protein leaks occur, which ultimately slows down blood flow, resulting in blood clots and swelling of the limbs (edema).”

The study sampled 60 diabetic patients suffering from DM being treated with insulin for at least three years at the Chieti-Pescara University in Italy. In addition to their insulin treatment, patients received 150 mg of Pycnogenol orally daily for one month. The control group, 50 percent of the sample, received a placebo. Measurements of blood flow were measured by laser Doppler.

Measurements were taken when patients were lying down and standing up. The capillary adaptation to increased pressure from lying down to standing is generally impaired, due to vessel failure and increase of pressure in capillaries for individuals who suffer from DM.

Results showed that when patients were lying down, Pycnogenol treatment improved capillary blood flow by 34 percent, compared to 4.7 percent in the placebo group. When patient’s blood flow was measured in a standing position, Pycnogenol treatment improved capillary blood flow by 68 percent, compared to 8 percent in the placebo group.

Capillary leakage was recorded by measuring ankle swelling, which develops ten minutes after passing from lying down to standing up. After Pycnogenol treatment, swelling was 17 percent lower, compared to 2.6 percent in the placebo group.

“The rapid improvement of microvessel complication with Pycnogenol in just four weeks is clinically remarkable,” said Dr. Belcaro, who has been a large part of previous Pycnogenol and diabetes related studies.

In July, a study was published supporting diabetic foot ulcer treatment with Pycnogenol. Results revealed almost 75 percent decrease in ulcer size in patients who supplemented with both oral and local Pycnogenol. Previous research supports Pycnogenol treatment to be highly effective for prevention of diabetic retinopathy and to be effective in lowering glucose levels and increasing the health of blood vessels in patients with type II diabetes. Previous research may be found at

About Pycnogenol

Pycnogenol is a natural plant extract originating from the bark of the Maritime pine that grows along the coast of southwest France and is found to contain a unique combination of procyanidins, bioflavonoids and organic acids, which offer extensive natural health benefits. The extract has been widely studied for the past 35 years and has more than 220 published studies and review articles ensuring safety and efficacy as an ingredient. Today, Pycnogenol is available in more than 500 dietary supplements, multi-vitamins and health products worldwide. For more information or a copy of this study, visit


Natural Health Science Inc., (NHS) based in Hoboken, New Jersey, is the North American distributor for Pycnogenol (pic-noj-en-all) brand French Maritime Pine Bark Extract on behalf of Horphag Research. Pycnogenol is a registered trademark of Horphag Research Ltd., Guernsey, and its applications are protected by U.S. patents #5,720,956 / #6,372,266 and other international patents. NHS has the exclusive rights to market and sell Pycnogenol in North America and benefits from more than 35 years of scientific research assuring the safety and efficacy of Pycnogenol as a dietary supplement. For more information about Pycnogenol visit our web site at


Melanie Nimrodi
[email protected]
MWW Group

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