Research Capsule

Study claim: A water-soluble cinnamon extract reduces fasting blood-sugar levels in patients with type 2 diabetes.

Published: Mang B, et al. Effects of a cinnamon extract on plasma glucose, HbA, and serum lipids in diabetes mellitus type 2. Eur J Clin Invest 2006 May;36(5):340-4.

Abstract: According to previous studies, cinnamon may have a positive effect on the glycaemic control and the lipid profile in patients with diabetes mellitus type 2. The aim of this trial was to determine whether an aqueous cinnamon purified extract improves glycated haemoglobin A1c (HbA1c), fasting plasma glucose, total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triacylglycerol concentrations in patients with type 2 diabetes.

A total of 79 patients with diagnosed diabetes mellitus type 2 not on insulin therapy but treated with oral antidiabetics or diet were randomly assigned to take either a cinnamon extract or a placebo capsule three times a day for four months in a double-blind study. The amount of aqueous cinnamon extract corresponded to 3g/day cinnamon powder.

The mean absolute and percentage differences between the pre- and post-intervention fasting plasma glucose level of the cinnamon and placebo groups were significantly different. There was a significantly higher reduction in the cinnamon group (10.3 per cent) than in the placebo group (3.4 per cent). No significant intragroup or intergroup differences were observed regarding HbA1c, lipid profiles, or differences between the pre- and postintervention levels of these variables. The decrease in plasma glucose correlated significantly with the baseline concentrations, indicating that subjects with a higher initial plasma glucose level may benefit more from cinnamon intake. No adverse effects were observed.

The cinnamon extract seems to have a moderate effect in reducing fasting plasma glucose concentrations in diabetic patients with poor glycaemic control.

Potential applications: GRAS for foods and suitable for supplements, Cinnulin PF benefits diabetics and those seeking blood-sugar control.

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+1 941 342 0007

Study claim: Bioavailability of selenium was greatest for selenomethionine (as Selenium SeLECT from Sabinsa Corporation), less for high-selenium yeast and the least for sodium selenite.

Published: Burk R, et al. Effects of chemical form of selenium on plasma biomarkers in a high-dose human supplementation trial. Cancer Epidemiol Biomarkers Prev 2006 April;15(4):804-10.

Abstract: When consumed, selenium enters the body to form selenoproteins and glutathione, the body's antioxidant immune system detoxifier. Intervention trials with different forms of selenium are under way to assess the effects of selenium supplements on the incidence of cancer and other diseases. Plasma selenium biomarkers respond to selenium administration and might be useful for assessing compliance and safety.

The present study characterised the effects of selenium supplementation on plasma selenium biomarkers and urinary selenium excretion in selenium-replete subjects. Moderate (200mg/day) to large (600mg/day) selenium supplements in the forms sodium selenite, high-selenium yeast (yeast), and L-selenomethionine were administered.

Subjects were randomised into 10 groups — placebo and three dose levels of each form of selenium. Plasma biomarkers (selenium concentration, selenoprotein P concentration and glutathione peroxidase activity) were determined before supplementation and every four weeks for 16 weeks. Urinary selenium excretion was determined at 16 weeks.

Supplementation with selenomethionine and yeast raised the plasma selenium concentration in a dose-dependent manner. Selenite did not. The increased selenium concentration correlated with the amount of selenomethionine administered. Neither glutathione peroxidase activity nor selenoprotein P concentration responded to selenium supplementation. Urinary selenium excretion was greater after selenomethionine than after selenite, with excretion after yeast being intermediate and not significantly different from either of the other two.

Plasma selenium concentration is useful in monitoring compliance and safety of selenium supplementation as selenomethionine but not as selenite. Plasma selenium seems to reflect the senomethionine content of yeast but not the other yeast selenium forms. As judged by urinary selenium excretion, selenium as selenomethionine is better absorbed than selenite.

Potential applications: Selenium SeLECT, an organic, amino acid-bounded selenium compound, is suitable for supplemental delivery systems.

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+1 732 777 1111

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