Research capsule

Beneo-OraftiVital Stats: Beneo-Orafti's Synergy1 FOS-enriched inulin
Study claim: The prebiotics inulin and oligofructose enhance absorption of calcium in the colon, which also confirms the ingredients' potential to support bone health and prevent osteoporosis. The mechanism-of-action study will also be helpful in designing other prebiotic products.

Published: Abrams SA, et al. An inulin-type fructan enhances calcium absorption primarily via an effect on colonic absorption in humans. J Nutr. 2007 Oct;137(10):2208-12.

Abstract: Calcium absorption efficiency and bone mineral mass are increased in adolescents who regularly consume inulin-type fructans (ITF). The mechanism of action in increasing absorption is unknown but may be related to increased colonic calcium absorption. Researchers conducted a study in young adults designed to evaluate these mechanisms with a kinetic technique using (42)Ca orally and (46)Ca-dosed iv. Those who responded to eight weeks of supplementation with 8g of a mixed short- and long-degree of polymerisation ITF by increasing their calcium absorption had kinetic measurements analyzed to evaluate the time course of absorption. The area under the curve of the oral tracer in the blood during the 26 hours after dosing was calculated and the time dependence of increased absorption determined.

Eight young adults (of 13 studied), with mean calcium intake approximately 900mg/day, responded to the ITF with an increased calcium absorption of at least three per cent. In responders, absorption increased from 22.7 +/- 11.3 per cent to 31.0 +/- 15.3 per cent. Colonic absorption, defined as absorption that occurred >seven hours after oral dosing, represented 69.6 +/- 18.6 per cent of the increase, or 49 +/- 28mg/day.

These findings suggest that, in those who respond to ITF, its effects on calcium absorption occur principally in the colon. This benefit to ITF may be especially important when absorption in the small intestine is impaired for anatomic or physiological reasons.

Potential applications: Orafti Synergy1 is suitable for most food applications including dairy, baked goods, soy drinks, cereal products, fillings and glazings, meal replacers, and supplements.

More info:
+1 973 867 2141

OptiMSMVital stats: Bergstrom Nutrition's OptiMSM
Study claim: OptiMSM may protect articular cartilage and reduce inflammation in early osteoarthritis.

Published: Oshima Y, et al. The effect of distilled methylsulfonylmethane (MSM) on human chondrocytes in vitro. Osteoarthritis Cartilage 2008;15 (Suppl C): C123.

Abstract: The study examined the effect of OptiMSM at varying concentrations on four grades of articular cartilage from post-mortem human knees, from healthy to osteoarthritic. Researchers focused on the expression of specific genes related to cartilage degradation and markers of inflammation, called cytokines, including TNF-alpha and IL-1. Over-expression of these genes and their related proteins are associated with the progression of osteoarthritis. The MSM concentrations were estimated to correspond to human oral dosing at between 0 and 30g/day.

In Grade II osteoarthritis, chondrocytes treated with MSM at the concentration of 12mcg/ml demonstrated a strong trend for MSM to reduce the mRNA expression of inflammatory markers: TNF-alpha -33 per cent and IL-1 -29 per cent when compared to lower concentrations of MSM and control. These results did not apply for osteoarthritis chondrocytes of Grade III or IV. MSM did not show an increase in proteoglycan synthesis in cultured chondrocytes or an increase of cartilage matrix production in normal and osteoarthritic chondrocytes at the mRNA level.

MSM might have an ability to protect articular cartilage in early osteoarthritis by reducing expression of inflammatory cytokinds. The effective concentration of 12mcg/ml MSM correlates with the dosage used in a recent clinical trial — 3g twice daily for a total of 6g/day for 12 weeks. MSM did not elicit an anabolic response in this study.

Potential applications: OptiMSM is organic sulfur that appears as a white, crystalline, water-soluble powder that is available in a variety of topical applications and internal dosage types. It is nontoxic, nonallergenic and always 99.9 per cent pure. Bergstrom is in the develoment stages of bringing OptiMSM to the functional-foods market.

More info:
+1 360 693 1883

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