Vital Stats: Carotech's gamma-tocotrienol
Study claim: Gamma-tocotrienol is the most potent form of tocotrienol for cardiovascular protection.
Published: Das S, et al. Cardioprotection with palm oil toco-trienols: comparison of different isomers. Am J Physiol Heart Circ Physiol 2008 Feb;294(2):H970-8.
Abstract: A team of researchers from the Cardiovascular Research Center at the University of Connecticut recently found the cardioprotective ability of the tocotrienol-rich fraction (TRF) from red palm oil. In this present study, they compared the cardioprotective abilities of different isomers of tocotrienol against TRF because tocotrienol is now known to function as a potent neuroprotective agent against stroke.
Rats were randomly assigned to one of the following groups: animals were given either 0.35 per cent, one per cent, or 3.5 per cent TRF for two different periods of time (two or four weeks), or 0.03, 0.3, or 3mg/kg body weight of one of the isomers of tocotrienol (alpha, gamma or delta) for four weeks; control animals were given, by gavage, vehicle only.
After two or four weeks, rats were killed, and their hearts were then subjected to 30 minutes of global ischemia followed by two hours of reperfusion. Dose-response and time-response experiments revealed that the optimal concentration for TRF was 3.5 per cent TRF and 0.3mg/kg body weight of tocotrienol given for four weeks. TRF as well as all the isomers of tocotrienol used provided cardioprotection, as evidenced by their ability to improve postischemic ventricular function and reduce myocardial infarct size. The gamma-isoform of tocotrienol was the most cardioprotective of all the isomers, followed by the alpha- and delta-isoforms.
Potential applications: Gamma-tocopherol is a supplemental ingredient suitable for cardioprotective formulations or in a full-spectrum vitamin E format.
Vital stats: Triarco's Aminogen, a plant-based enzyme system
Study claim: Aminogen triples rates of whey-protein absorption.
Published: Oben J, et al. An open label study to determine the effects of an oral proteolytic enzyme system on whey protein concentrate metabolism in healthy males. J Intl Soc Sports Nutr 2008 Jul 24;5:10. www.jissn.com/content/5/1/10
Abstract: Aminogen is a patented blend of digestive proteases from Aspergillus niger and Aspergillus oryzae. Researchers tested if it would increase the in vivo absorption rate of processed whey protein concentrate (WPC) over control values. It also investigated if any increase would be sufficient to significantly alter nitrogen (N2) balance and C-reactive protein (CRP) levels over control values as further evidence of an increased WPC absorption rate.
Two groups of healthy male subjects were assigned a specified balanced diet before and after each of the two legs of the study. In the first leg, each control group (CG) was dosed with 50g WPC following an overnight fast. Nine days later each test group (TG) was dosed following an overnight fast with 50g WPC containing either 2.5g (A2.5) or 5g (A5) Aminogen. Blood samples were collected during each leg at 0 hr, 0.5 hr, one hr, two hr, three hr, 3.5 hr and four hr for amino acid (AA) and CRP analyses.
After baseline subtraction, the mean area under the concentration time curve (AUC) was significantly greater in each TG compared to the corresponding CG. Comparison of the mean AUC between each TG and each CG was not significantly different. Total serum amino acid (TSAA) levels were significantly greater in each TG compared to the corresponding CG. They were also significantly different between each TG but not between each CG. All individual serum amino acid (ISAA) levels (18 amino acids were quantified) in TG-A2.5, except for glycine, histidine, methionine and serine, were significantly higher than in CG-A2.5 at four hr. All ISAA levels in TG-A5 except for methionine and serine, were significantly higher than in CG-A5 at four hr. The N2 balance and CRP levels were significantly higher in each TG compared to the corresponding CG.
Potential applications: Aminogen is GRAS for protein drinks, protein bars, meal replacement bars and smoothies. It is also suitable for capsules and tablets. Conditions include sports nutrition, weight loss and satiety, sarcopenia, and cardio and digestive health.
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