Research capsule

GlisodinStudy claim: Supplementation with GliSODin from PL Thomas prior to an invasive surgical procedure was significantly better than placebo in inhibiting several measures of cellular damage, including DNA damage and protection of spinal-cord tissues, without negative effects or impairing organ function.

Published: Jochen Kick, et al. Effects of a cantaloupe melon extract/wheat gliadin biopolymer during aortic cross-clamping. Intensive Care Med 2007 Apr;33(4):694-702.

Abstract: It has been shown in healthy volunteers that a cantaloupe-melon extract chemically combined with wheat gliadin (melon extract/gliadin) and containing SOD, catalase and residual glutathione peroxidase (GPx) protects against DNA strand-break damage induced by hyperbaric oxygen (HBO), a well-established model of DNA damage resulting from oxidative stress. Aortic cross-clamping is a typical example of ischemia/reperfusion injury-related oxidative stress. Researchers therefore investigated whether this melon extract/gliadin would also reduce DNA damage after aortic cross-clamping and reperfusion.

This prospective, randomised, controlled experimental study used 18 anesthetised, mechanically ventilated and instrumented pigs. After 14 days of oral administration of 1,250mg melon extract/gliadin (n=9) or vehicle (n=9), animals underwent 30 minutes of thoracic aortic cross-clamping and four hours of reperfusion. Before clamping, immediately before declamping, and at two and four hours of reperfusion, researchers measured blood isoprostane (immunoassay) and malondialdehyde concentrations (fluorimetric thiobarbituric acid test), SOD, catalase and GPx activities (spectrophotometric kits), NO formation (nitrate+nitrite; chemoluminescence), DNA damage in whole blood samples, and isolated lymphocytes exposed to hyperbaric oxygen (comet assay). Organ function was also evaluated. Kidney and spinal-cord specimens were analysed for apoptosis. The melon extract/gliadin blunted the DNA damage, reduced spinal-cord apoptosis and attenuated NO release, and without any effect on lipid peroxidation and organ function. Pre-treatment with the oral melon extract/gliadin may be a therapeutic option to reduce oxidative cell injury affiliated with aortic cross-clamping.

Potential applications: GliSODin may be an adjunctive measure for elective surgery and/or used as nutritional support under conditions of prolonged periods of enhanced oxidative stress. It is available for supplements.

More info:
+1 973 984 0900

SvetolStudy claim: Svetol, Berkem's unique extract of decaffeinated green coffee beans, reduces body mass index and increases the ratio of lean mass to fat mass.

Published: Dellalibera SSA, et al. Svetol green coffee extract, induces weight loss and increases the lean-to-fat-mass ratio in volunteers with overweight problems. Phytotherapie 2006;4(4):194-7.

Abstract: Several previous epidemiologic studies have shown that individuals with an average-to-high daily consumption of coffee reduced their risk of developing type 2 diabetes. Other works have demonstrated that coffee consumption improved glucose tolerance, which led to a protective effect against developing type 2 diabetes. Some researchers claim that coffee's glucose tolerance activity may result from the combination of several active ingredients, vs just one of its components.

This placebo-controlled, double-blind clinical study assessed the slimming action of Sveltol, a water-soluble extract of decaffeinated green coffee. Thirty patients between 19 and 75 years old, with a BMI higher than 25, were administered a 200mg capsule of Svetol twice a day, while 20 others received a placebo. After 60 days of treatment, the treatment group experienced a significant mean reduction in weight of 5.7 per cent (average reduction of 5kg), and an increase in the lean-to-fat-mass ratio of four per cent, as compared to only 2.9 per cent and 1.5 per cent, respectively, in the placebo group.

Researchers concluded that Svetol's active molecules could decrease the glucose intestinal absorption and inhibit the glucose-6-phosphatase. Thanks to the inhibition of G-6-Pase, the body has to get energy from another source — to burn fat from the adipose tissue.

Potential applications: Successfully launched in Europe, Svetol is the new active ingredient for weight management. Svetol is suited for use in dietary supplements, and holds great potential to be used in functional foods and beverages.

More info:
+1 64 62 74 12 92

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