Taking up the cause for menopause

The landscape of women's health was forever altered in 2002 when the National Institutes of Health (NIH) abruptly stopped its research into hormone replacement therapy (HRT) in menopausal women. Since then, millions of people have been left looking for other alternatives.

The landscape of women's health was forever altered in 2002 when the National Institutes of Health (NIH) abruptly stopped its research into hormone replacement therapy (HRT) in menopausal women.

Five years into the eight-year study, the researchers realized that HRT was putting women's lives in danger with elevated risk of coronary heart disease, stroke, pulmonary embolism, breast cancer and even dementia.

Since then, millions of people have been left looking for other alternatives. In extreme cases, hot flashes in women going through menopause can occur more than 30 times a day, last in duration from seconds to 10 minutes or more, and, for some, persist for five years or longer.

The good news about the bad news has been a renewed interest in research into herbal and nutritional remedies for menopause symptoms. NIH is currently funding several major clinical trials, and there appears to be fresh attention being paid to nature's two sources of phytoestrogens: isoflavones and lignans.

Soy Isoflavones
It was the disaster of the HRT trial that prompted a team at Harvard Medical School to study the effects of the soy isoflavone daidzein on menopause symptoms.

What they found, in 2008, is that the compound can reduce the incidence of hot flushes by 52 percent. In addition, no side effects were reported during the 12-week trial with 147 post-menopausal women.

Isoflavones are well-known phytoestrogens — active substances derived from plants that have a weak estrogenlike action. They have been shown to promote heart health and help maintain bone health in post-menopausal women.

In the study, women received daily supplements of either the daidzein-rich isoflavone-aglycone (DRI) supplement at a dose of either 40 or 60mg, or a placebo. The ingredient, AglyMax, is manufactured by Tokyo-based Nichimo Co, and is extracted from soy germ fermented with Koji fungus.

The group receiving the lower dose reported a 52 percent reduction in hot flashes, versus 51 percent in the high-dose group and 39 percent in the placebo group.

Editor's Picks:

Black cohosh: Cumicifuga racemosa is one of the best-studied traditional herbs for menopause. One of its compounds, fukinolic acid, has been shown to have estrogenic activity in vitro.
Isoflavones and lignans: As nature's two phytoestrogens, most research indicates they are efficient fillers when the body's internal estrogen levels begin to deplete.
Soy foods: We're talking edamame, tofu, tempeh and soy milk. One or two servings a day will net you about 40mg isoflavones, all housed in a safe and sound food matrix.

"What we found was that the degree of improvement in women taking the DRI supplement was similar to that of alternative therapies such as a serotonin inhibitor, but without their negative side effects," stated researcher Hope Ricciotti.

Then, a 2009 study in China, published in the Journal of the American Medical Association, found benefits to soy consumption among female survivors of breast cancer. This is significant given lingering concern over the effects of phytoestrogens in soy, or a potential negative interplay between soy isoflavones and a tamoxifen drug regimen.

The researchers analysed data from the Shanghai Breast Cancer Survival Study, a study of 5,042 female breast cancer survivors aged 20 to 75 in China. Women with the highest intake of soy protein had a 29 percent lower risk of death and a 32 percent lower risk of breast-cancer recurrence compared to patients with the lowest intake of soy protein.

After about four years of follow-up, 44 total deaths and 534 recurrences were documented. Soy-food intake, as measured by either soy protein or soy isoflavone intake, was inversely associated with mortality and recurrence, said the researchers.

The researchers noted significant reductions in both mortality and breast-cancer recurrence with increasing soy-protein intake, up to a level of 11g per day. The inverse association was evident among women with either estrogen receptor—positive or -negative breast cancer, and was present in both users and nonusers of tamoxifen.

"This study suggests that moderate soy-food intake is safe and potentially beneficial for women with breast cancer," the researchers concluded.

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geniVida is pure soy-free genistein shown to reduce to reduce menopausal symptoms including number and duration of hot flashes and to significantly increase bone mineral density in post menopausal women. geniVida is safe, patented, allergen-free, non-GMO and GRAS and can be incorporated into food, beverage and supplement formulations for mature men and women.
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Gencor Nutrients Inc.
GENOPAUSE is an herbal, nonestrogenic formula for women experiencing symptoms of post menopause. In a 156 patient, double-blind, randomized, placebo-controlled human clinical study Genopause showed excellent results in reducing such symptoms as hot flashes, palpitations, insomnia, nervousness, general weakness, parasthesia, arthalgia and myalgia.
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Anaheim, California, USA

Institut Rosell-Lallemand
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UAS Laboratories, Inc.
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Breakthrough, patent-pending women's health formula containing premier probiotic blend of DDS probiotics (Lactobacillus acidophilus DDS-1, B. longum, B. bifidum, B. lactis) at a combined potency of 5 billion CFU/g. plus natural D-mannose and Cranberry fruit extract. Supports urinary tract health, digestive health, immune function and maintains healthy yeast levels.
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