Embria® Health Sciences, immune health ingredient EpiCor
Study claim: EpiCor significantly increases NK cell activation and serum antioxidant levels within two hours. Other rapid changes included effects on T and natural killer (NK) cell circulation.
Published: Jense, G., et al. Antioxidant Bioavailability and Rapid Immune-Modulating Effects After Consumption of a Single Acute Dose of a High-Metabolite Yeast Immunogen: Results of a Placebo-Controlled Double-Blinded Crossover Pilot Study. J Med Food 14 (9) 2011, 1002–1010.
Abstract: The objective of this study was to investigate the acute effects on circulating lymphocyte subsets, antioxidant status, and cytokine proﬁle after consumption of EpiCor (EP), a dried fermentate from Saccharomyces cerevisiae, using a placebo-controlled randomized crossover study design with 12 healthy adult human subjects.
EP contains high levels of bioavailable antioxidants and strongly activates natural killer (NK) cells in vitro. EP consumption has been shown to increase erythrocyte hematocrit levels, boost mucosal immune protection, reduce cold/ﬂu symptoms, reduce seasonal allergy symptoms and the need for rescue medication, and increase salivary secretory immunoglobulin A levels. This warranted further study on immune effects in humans.
A within-subject analysis of data collected before and at 1 and 2 hours after consumption of a single dose of 500 mg of EP versus placebo was performed. A transient reduction in circulating T and NK cell numbers was observed 2 hours, suggesting that homing and recirculation of these cells, as part of healthy immune surveillance, were supported by EP. A rapid increase in serum interferon-c was observed at 1 hour post-consumption and may have contributed to the effects seen on NK and T cell subsets. A signiﬁcant increase in serum antioxidant protection was seen 2 hours after consumption.
Consumption of a single 500 mg dose of EP provides a rapid and transient effect on the trafficking and activation status of speciﬁc lymphocyte subsets, as well as increased antioxidant protection.
Potential applications: The study demonstrates that some of the effects of EpiCor can be seen in as little as two hours, which may be useful in the immune health category.
Vital stats: Helios Corporation and Sunbio Corporation, EstroG-100
Study claim: EstroG-100 showed significant improvement in 9 of 11 end points, along with an additional significant improvement in vaginal dryness. Also, hGH levels increased by 100 percent, which can be directly attributed to improvements in energy level, skin moisture and tone.
Published: Chang, A., Kwak, B.-Y., Yi, K. and Kim, J. S. (2011), The Effect of Herbal Extract (EstroG-100) on Pre-, Peri- and Post-Menopausal Women: A Randomized Double-blind, Placebo-controlled Study. Phytotherapy Research. doi: 10.1002/ptr.3597
Abstract: This clinical research study was designed to evaluate the efficacy of a new herbal product, EstroG-100, containing a mixture of standardized extracts of Cynanchum wilfordii, Phlomis umbrosa and Angelica gigas, on menopausal symptoms.
This randomized double-blind, placebo-controlled trial was performed for 12 weeks with 64 pre-, peri- and postmenopausal White Hispanic, White non-Hispanic and African American women who were randomly allocated to either the EstroG-100 group (n=31) or the placebo group (n=33). Primary end-points were the mean change in scores of the Kupperman menopause index (KMI) that evaluates 11 symptoms, and the mean change in scores of vaginal dryness. The mean KMI score was significantly reduced in the EstroG-100 group from 29.5±7.4 at baseline to 11.3 ± 5.8 (p
In conclusion, EstroG-100 significantly improved the menopausal symptoms of pre-, peri- and post-menopausal women without weight gain or any serious side effects.
Potential applications: As an ingredient for women experiencing pre-, peri-, and post-menopause.