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Vitamin E TPGS USP/NF: Isochem Now Able to Supply Commercial Quantities

Isochem’s extensive experience and know how in development of robust and competitive industrial processes came to an end in 2007 when first industrial quantities of Vitamin E TPGS were produced (Vitamin E, D-alpha-tocopheryl polyethylene glycol 1000 succinate).

Vitamin E TPGS is a multi-role excipient used in nutraceutical and pharmaceutical applications. Vitamin E TPGS has shown proven and recognized properties to improve bioavailability of poorly absorbed drugs acting as a solubilizer and as an absorption and permeability enhancer. As a water soluble compound, Vitamin E TPGS is also used as an efficient source of Vitamin E, both for therapeutic purposes and in nutrition.

End of 2008 Isochem will have manufactured tens of tons of Vitamin E TPGS to serve various international customers strengthening its position as a key partner of major actors in the pharmaceutical market.

Xavier Jeanjean, Sales Director, Isochem, explains: “Our experience as a manufacturer of Pharmaceutical actives gives us some key advantages to compete in the Vitamin E TPGS market. This product is manufactured in one of our state of the art FDA audited facility, located in France and operating in full compliance with cGMP guidelines. Furthermore, we offer our customers an optimised supply security with the qualification of the Vitamin E TPGS process into a second cGMP site. Our ability to rapidly enlarge our production capacity is consequently enabling us to fulfill our customers growing demands”.

Operating in the fine chemicals market, ISOCHEM, a subsidiary of GROUPE SNPE, is a specialist in complex synthesis processes. It covers a wide variety of organic synthesis reactions, and offers proven expertise in reactions at very low temperatures, as well as nitration, phosgenation and hydrogenation. ISOCHEM offers the exclusive, customized manufacture of innovative molecules for customers in the pharmaceuticals, plant protection and specialty intermediates markets, under strictly confidential conditions.

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